DARC Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)
-
- Target Alle DARC Proteine anzeigen
- DARC (Duffy Blood Group, Chemokine Receptor (DARC))
- Protein-Typ
- Recombinant
- Proteineigenschaft
- Transcript Variant 2
-
Spezies
- Human
-
Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses DARC Protein ist gelabelt mit Myc-DYKDDDDK Tag.
- Applikation
- Antibody Production (AbP), Standard (STD)
- Produktmerkmale
-
- Recombinant human CD234 / DARC (transcript variant 2) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Reinheit
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product DARC Protein
-
-
- Applikationshinweise
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Kommentare
-
The tag is located at the C-terminal.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
- Target
- DARC (Duffy Blood Group, Chemokine Receptor (DARC))
- Andere Bezeichnung
- Cd234,darc (DARC Produkte)
- Synonyme
- DARC Protein, FY Protein, ACKR1 Protein, CCBP1 Protein, CD234 Protein, Dfy Protein, GPD Protein, GpFy Protein, WBCQ1 Protein, AA162249 Protein, Ackr1 Protein, ESTM35 Protein, Duffy blood group, chemokine receptor Protein, atypical chemokine receptor 1 (Duffy blood group) Protein, atypical chemokine receptor 1 Protein, DARC Protein, ACKR1 Protein, Ackr1 Protein
- Hintergrund
- Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. [UniProtKB/Swiss-Prot Function]
- Molekulargewicht
- 35.4 kDa
- NCBI Accession
- NP_002027
-