Coagulation Factor X Protein (F10) (Myc-DYKDDDDK Tag)

Produktnummer ABIN2712927

Produktdetails

Target: Coagulation Factor X (F10)

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses Coagulation Factor X Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human Coagulation factor X (F10) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: Coagulation Factor X (F10)

Abstract: F10 Produkte

Synonyme: FX Protein, FXA Protein, Cf10 Protein, fX Protein, fi12c10 Protein, wu:fi12c10 Protein, F10 Protein, f10 Protein, coagulation factor X Protein, Coagulation factor X Protein, coagulation factor 10 L homeolog Protein, F10 Protein, f10 Protein, CpipJ_CPIJ012712 Protein, CpipJ_CPIJ014863 Protein, CpipJ_CPIJ016937 Protein, CpipJ_CPIJ017791 Protein, fa10 Protein, f10.L Protein

Hintergrund: This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.

Molekulargewicht: 52.3 kDa

NCBI Accession: NP_000495