CYP3A4 Protein (Myc-DYKDDDDK Tag)

Produktnummer ABIN2712775

Produktdetails

Target: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses CYP3A4 Protein ist gelabelt mit Myc-DYKDDDDK Tag.

Applikation: Antibody Production (AbP), Standard (STD)

Produktmerkmale:

• Recombinant human CYP3A4 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Reinheit: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Anwendungsinformationen

Applikationshinweise: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Kommentare:

The tag is located at the C-terminal.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Lagerung: -80 °C

Informationen zur Lagerung: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Antigendetails

Target: CYP3A4 (Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))

Andere Bezeichnung: Cyp3a4 (CYP3A4 Produkte)

Synonyme: CP33 Protein, CP34 Protein, CYP3A Protein, CYP3A3 Protein, CYPIIIA3 Protein, CYPIIIA4 Protein, HLP Protein, NF-25 Protein, P450C3 Protein, P450PCN1 Protein, MGC108372 Protein, CYP3A80 Protein, CYP3A4 Protein, CYP3A21 Protein, CYPIIIA21 Protein, CYP3A12 Protein, cytochrome P450 family 3 subfamily A member 4 Protein, cytochrome P450 family 3 subfamily A member 43 Protein, cytochrome P450 3A4 Protein, cytochrome P450, subfamily IIIA, polypeptide 4 Protein, cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 Protein, cytochrome P450, family 3, subfamily A, polypeptide 4 Protein, CYP3A4 Protein, CYP3A43 Protein, PTRG_01782 Protein, PTRG_06060 Protein, cyp3a4 Protein

Hintergrund: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified.

Molekulargewicht: 57.2 kDa

NCBI Accession: NP_059488

Pathways: Steroid Hormone Biosynthesis