NR1H4 Protein (His tag)
-
- Target Alle NR1H4 Proteine anzeigen
- NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))
- Protein-Typ
- Recombinant
-
Spezies
- Human
-
Quelle
- Escherichia coli (E. coli)
- Aufreinigungstag / Konjugat
- Dieses NR1H4 Protein ist gelabelt mit His tag.
- Applikation
- Protein Interaction (PI)
- Produktmerkmale
- Recombinant FXR is isolated from an E. coli strain that carries the coding sequence of the human FXR under the control of a T7 promoter (accession number U68233). The purified recombinant protein has an amino terminal polyhistidine tag and is greater than 90 % homogeneous and contains no detectable protease, DNase and RNase activity.
- Reinheit
- The purified recombinant protein has an amino terminal polyhistidine tag and is greater than 90 % homogeneous and contains no detectable protease, DNase and RNase activity.
- Top Product
- Discover our top product NR1H4 Protein
-
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 363-472) protein (GST tag)
NR1H4 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 1-476) protein (GST tag)NR1H4 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AP, AA
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 1-486) protein (Strep Tag)Crystallography grade NR1H4 Spezies: Human Wirt: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 1-488) protein (Strep Tag)Crystallography grade NR1H4 Spezies: Maus Wirt: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) (AA 1-476), (Isoform 3) protein (His-SUMO Tag)NR1H4 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 90 % SDS
Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4) proteinNR1H4 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant WB, SDS, ELISA, IP
-
- Applikationshinweise
- Recombinant FXR is suitable for DNA and protein-protein interaction assays. 20 ng is sufficient for gelshift assays and 100 ng is sufficient for protein-protein interaction studies. The molecular weight of the protein is ~55 kDa. NOTE: The presence of Poly [d(I-C)] in buffers may affect protein functionality and should be avoided.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 0.1 μg/μL
-
- Target
- NR1H4 (Nuclear Receptor Subfamily 1, Group H, Member 4 (NR1H4))
- Andere Bezeichnung
- FXR (NR1H4 Produkte)
- Synonyme
- zgc:110190 Protein, zgc:92742 Protein, NR1H4 Protein, BAR Protein, FXR Protein, HRR-1 Protein, HRR1 Protein, RIP14 Protein, AI957360 Protein, Fxr Protein, Rxrip14 Protein, nuclear receptor subfamily 1, group H, member 5 S homeolog Protein, nuclear receptor subfamily 1, group H, member 4 Protein, nuclear receptor subfamily 1 group H member 4 Protein, nr1h5.S Protein, nr1h4 Protein, NR1H4 Protein, Nr1h4 Protein
- Hintergrund
- The farnesoid X receptor (FXR) or nuclear receptor subfamily 1, group H, member 4 (NR1H4) is a nuclear receptor that, when activated, translocates to the nucleus where it interacts with certain proteins, including RXR and PPARGC1A, forming heterodimers that bind to hormone response elements on DNA and modulate gene expression. One of the primary functions of FXR is to suppress bile acid synthesis when levels are high by inhibiting the transcription of cholesterol 7 alpha-hydroxylase (CYP7A1) gene that expresses CYP7A1, the rate-limiting enzyme in bile acid synthesis from cholesterol.
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Carbohydrate Metabolic Process
-
