GDF3 Protein

Produktnummer ABIN2468472

Produktdetails

Target: GDF3 (Growth Differentiation Factor 3 (GDF3))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: Escherichia coli (E. coli)

Sequenz: AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG

Produktmerkmale: Biological activity was determined by its ability to inhibit induced alkaline phosphatase production by ATDC - 5 chondrogenic cells. The ED50 for this effect is 100 - 150 ng/mL.

Reinheit: < 98 % by SDS-PAGE gel and HPLC analyses.

Endotoxin-Niveau: Endotoxin level is less than 0.1 ng per μg (1 EU/μg).

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Handhabung: As with any protein, exposing GDF-3 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Lagerung: -20 °C

Informationen zur Lagerung: The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted GDF-3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.

Haltbarkeit: 24 months

Antigendetails

Target: GDF3 (Growth Differentiation Factor 3 (GDF3))

Andere Bezeichnung: GDF-3 (GDF3 Produkte)

Synonyme: KFS3 Protein, MCOP7 Protein, MCOPCB6 Protein, C78318 Protein, Gdf-3 Protein, Vgr-2 Protein, Vgr2 Protein, ecat9 Protein, RGD1564178 Protein, CVG1 Protein, der Protein, derriere Protein, gdf3-a Protein, vgr-2 Protein, vgr2 Protein, growth differentiation factor 3 Protein, growth differentiation factor 3 S homeolog Protein, GDF3 Protein, Gdf3 Protein, gdf3.S Protein

Hintergrund: GDF-3 is a member of the TGF-beta superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-beta family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes. Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.

Gen-ID: 9573

NCBI Accession: NP_065685

OMIM: 10190670

UniProt: Q9NR23