Pertussis Toxin (ARTC) (Active) Protein

Details zu Produkt Nr. ABIN2452202, Anbieter: Anmelden zum Anzeigen
Proteinname
Spezies
Bordetella pertussis
Quelle
Bordetella pertussis
Protein-Typ
Native
Biologische Aktivität
Active
Applikation
Functional Studies (Func)
Optionen
Hersteller
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Produktmerkmale This product was highly purified (>90 % pure) from Bordetella pertussis strain Tohama by the method of Skelton & Wong. Cytotoxicity of the PT was confirmed by morphological alteration of CHO cells after treatment with 0.1 ng/mL of PT.
Proteinname
Hintergrund Perrtussis toxin (PT) is a protein-based AB5-type exotoxin produced by Bordeterra pertussis. PT catalyzes the ADP-ribosylation of the alpha subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt and prevents intracellular signal transduction involving the G proteins. PT consists of one moplecule of each S1 (26 kDa), S2 (22 kDa), S3 (22 kDa), S5 (12 kDa) and two molecule of S4 (12 kDa).
Applikations-hinweise 1. Studies on the signal transduction of the trimeric GTP binding proteins.
2. Therapeutic role in treating a number of diseases including hypertention,viral and autoimumune inhibitions.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 83 µg/mL
Buffer 10 % glycerol, 10 mM phoshate buffer ( pH 7. 4), 137 mM NaCl
Lagerung -80 °C
Bilder des Herstellers
SDS-PAGE (SDS) image for Pertussis Toxin (ARTC) (Active) protein (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein
SDS-PAGE (SDS) image for Pertussis Toxin (ARTC) (Active) protein (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein (Image 2)
SDS-PAGE (SDS) image for Pertussis Toxin (ARTC) (Active) protein (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein (Image 3)
Cell Culture (CC) image for Pertussis Toxin (ARTC) (Active) protein (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein (Image 4)
Produkt verwendet in: Skelton, Wong: "Simple, efficient purification of filamentous hemagglutinin and pertussis toxin from Bordetella pertussis by hydrophobic and affinity interaction." in: Journal of clinical microbiology, Vol. 28, Issue 5, pp. 1062-5, 1990 (PubMed).

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