Pertussis Toxin (ARTC) (Active) Protein

Details zu Produkt Nr. ABIN2452202
Proteinname
Spezies
Bordetella pertussis
Quelle
Bordetella pertussis
Protein-Typ
Native
Biologische Aktivität
Active
Applikation
Functional Studies (Func)
Optionen
Produktmerkmale This product was highly purified (>90 % pure) from Bordetella pertussis strain Tohama by the method of Skelton & Wong. Cytotoxicity of the PT was confirmed by morphological alteration of CHO cells after treatment with 0.1 ng/mL of PT.
Proteinname
Hintergrund Perrtussis toxin (PT) is a protein-based AB5-type exotoxin produced by Bordeterra pertussis. PT catalyzes the ADP-ribosylation of the alpha subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt and prevents intracellular signal transduction involving the G proteins. PT consists of one moplecule of each S1 (26 kDa), S2 (22 kDa), S3 (22 kDa), S5 (12 kDa) and two molecule of S4 (12 kDa).
Applikations-hinweise 1. Studies on the signal transduction of the trimeric GTP binding proteins.
2. Therapeutic role in treating a number of diseases including hypertention,viral and autoimumune inhibitions.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 83 µg/mL
Buffer 10 % glycerol, 10 mM phoshate buffer ( pH 7. 4), 137 mM NaCl
Lagerung -80 °C
Bilder des Herstellers
Image no. 1 for Pertussis Toxin (ARTC) (Active) protein (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein (Image 1)
Image no. 2 for Pertussis Toxin (ARTC) (Active) protein (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein (Image 2)
Image no. 3 for Pertussis Toxin (ARTC) (Active) protein (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein (Image 3)
Image no. 4 for Pertussis Toxin (ARTC) (Active) protein (ABIN2452202) Pertussis Toxin (ARTC) (Active) protein (Image 4)
Produkt verwendet in: Skelton, Wong: "Simple, efficient purification of filamentous hemagglutinin and pertussis toxin from Bordetella pertussis by hydrophobic and affinity interaction." in: Journal of clinical microbiology, Vol. 28, Issue 5, pp. 1062-5, 1990 (PubMed).

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