LCP2 Protein (AA 1-533) (His tag,T7 tag)

Produktnummer ABIN2115473

Produktdetails

Target: LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-533

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses LCP2 Protein ist gelabelt mit His tag,T7 tag.

Verwendungszweck: Recombinant Human Lymphocyte Cytosolic Protein 2/LCP2 (C-6His, N-T7 tag)

Sequenz: MASMTGGQQM GRGSMALRNV PFRSEVLGWD PDSLADYFKK LNYKDCEKAV KKYHIDGARF LNLTENDIQK FPKLRVPILS KLSQEINKNE ERRSIFTRKP QVPRFPEETE SHEEDNGGWS SFEEDDYESP NDDQDGEDDG DYESPNEEEE APVEDDADYE PPPSNDEEAL QNSILPAKPF PNSNSMYIDR PPSGKTPQQP PVPPQRPMAA LPPPPAGRNH SPLPPPQTNH EEPSRSRNHK TAKLPAPSID RSTKPPLDRS LAPFDREPFT LGKKPPFSDK PSIPAGRSLG EHLPKIQKPP LPPTTERHER SSPLPGKKPP VPKHGWGPDR RENDEDDVHQ RPLPQPALLP MSSNTFPSRS TKPSPMNPLP SSHMPGAFSE SNSSFPQSAS LPPYFSQGPS NRPPIRAEGR NFPLPLPNKP RPPSPAEEEN SLNEEWYVSY ITRPEAEAAL RKINQDGTFL VRDSSKKTTT NPYVLMVLYK DKVYNIQIRY QKESQVYLLG TGLRGKEDFL SVSDIIDYFR KMPLLLIDGK NRGSRYQCTL THAAGYPLEH HHHHH

Produktmerkmale: Recombinant Human LCP2 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Pro533) of Human LCP2 fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM Tris,150 mM NaCl,20 % glycerol, pH 8.5.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: -80 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))

Andere Bezeichnung: Lymphocyte Cytosolic Protein 2/LCP2 (LCP2 Produkte)

Synonyme: AI323664 Protein, BB161688 Protein, SLP-76 Protein, SLP76 Protein, twm Protein, Slp76 Protein, lymphocyte cytosolic protein 2 Protein, Lcp2 Protein, LCP2 Protein

Hintergrund: Lymphocyte cytosolic protein 2(LCP2)contains a SAM domain and a SH2 domain. It is highly expressed in spleen, thymus and peripheral blood leukocytes, T-cell and monocytic cell lines, but expressed at lower level in B-cell lines. LCP2 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. It is phosphorylated after T-cell receptor activation by ZAP70, ITK and TXK, which leads to the up-regulation of Th1 preferred cytokine IL-2 during post-translational modification. Studies using LCP2-deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
Synonyms: Lymphocyte cytosolic protein 2,SH2 domain-containing leukocyte protein of 76 kDa,SLP-76 tyrosine phosphoprotein,SLP76,LCP2

Molekulargewicht: 62.6 kDa

UniProt: Q13094

Pathways: T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung