ITM2B Protein (AA 76-266) (His tag)

Produktnummer ABIN2115428

Produktdetails

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Protein-Typ: Recombinant

Proteineigenschaft: AA 76-266

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses ITM2B Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Integral Membrane Protein 2B/ITM2B/imBRI2 (C-6His)

Sequenz: YKYFALQPDD VYYCGIKYIK DDVILNEPSA DAPAALYQTI EENIKIFEEE EVEFISVPVP EFADSDPANI VHDFNKKLTA YLDLNLDKCY VIPLNTSIVM PPRNLLELLI NIKAGTYLPQ SYLIHEHMVI TDRIENIDHL GFFIYRLCHD KETYKLQRRE TIKGIQKREA SNCFAIRHFE NKFAVETLIC SVDHHHHHH

Produktmerkmale: Recombinant Human Integral Membrane Protein 2B/ITM2B is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Tyr76-Ser266) of Human ITM2B fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Andere Bezeichnung: ITM2B (ITM2B Produkte)

Synonyme: ABRI Protein, BRI Protein, BRI2 Protein, BRICD2B Protein, E25B Protein, E3-16 Protein, FBD Protein, imBRI2 Protein, AI256040 Protein, Bri Protein, Bri2 Protein, Bricd2b Protein, D14Sel6 Protein, E25BMM Protein, itm2b Protein, zgc:55770 Protein, zgc:85688 Protein, wu:fc05f02 Protein, MGC52745 Protein, MGC76131 Protein, ITM2B Protein, itm2bl Protein, wu:fb94b03 Protein, zgc:64142 Protein, integral membrane protein 2B Protein, integral membrane protein 2Ba Protein, integral membrane protein 2B L homeolog Protein, integral membrane protein 2b Protein, integral membrane protein 2Bb Protein, ITM2B Protein, Itm2b Protein, itm2ba Protein, itm2b.L Protein, itm2b Protein, itm2bb Protein

Hintergrund: Integral Membrane Protein 2B (ITM2B) is expressed in the Golgi and on the cell surface. ITM2B forms homodimer through disulfide-linked interaction with SPPL2A, SPPL2B and APP. ITM2B is expressed in brain and the other tissues. Defects in ITM2B cause cerebral amyloid angiopathy ITM2B-related type 1(CAA-ITM2B1) and amyloid angiopathy ITM2B-related type 2(CAA-ITM2B2). CAA-ITM2B1 is characterized by amyloid deposition in the walls of cerebral blood vessels and neurodegeneration in the central nervous system. CAA-ITM2B2 characterized by amyloid deposition in the walls of the blood vessels of the cerebrum, choroid plexus, cerebellum, spinal cord and retina.
Synonyms: Integral Membrane Protein 2B, Immature BRI2, imBRI2, Protein E25B, Transmembrane Protein BRI, Bri, ITM2B, BRI, BRI2

Molekulargewicht: 23.3 kDa

UniProt: Q9Y287