TNFSF13 Protein (AA 50-241)

Produktnummer ABIN2017647

Produktdetails

Target: TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))

Protein-Typ: Recombinant

Proteineigenschaft: AA 50-241

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Produktmerkmale: Measured by its ability to induce cell proliferation of RPMI 8226 Cells.
AA 50-241, expressed with an N-terminal Met.

Reinheit: > 95 % by SDS-PAGE and HPLC analyses

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against 20 mM acetic acid.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant mouse A Proliferation-inducing Ligand (rmApril) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rmApril should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: TNFSF13 (Tumor Necrosis Factor (Ligand) Superfamily, Member 13 (TNFSF13))

Andere Bezeichnung: A Proliferation-Inducing Ligand (April) (TNFSF13 Produkte)

Synonyme: APRIL Protein, CD256 Protein, TALL-2 Protein, TALL2 Protein, TRDL-1 Protein, ZTNF2 Protein, 2310026N09Rik Protein, April Protein, Tall2 Protein, Trdl1 Protein, SLAN Protein, ANP32B Protein, april Protein, tnf13 Protein, TNLG7B Protein, TNF superfamily member 13 Protein, tumor necrosis factor (ligand) superfamily, member 13 Protein, acidic leucine-rich nuclear phosphoprotein 32 family member B Protein, TNFSF13 Protein, Tnfsf13 Protein, LOC494442 Protein, tnfsf13 Protein

Hintergrund: A Proliferation-inducing Ligand (April)) also known as TNSF13A, Tall-2, and TRDL-1, is a member of the TNF ligand (TNFL) superfamily. April is most similar to B-cell activation factor (BAFF) with which it shares 30 % sequence identity, compete for two receptors, TACI and BCMA. APRIL is expressed at low levels in lymphoid tissue and is over-expressed by a number of tumors. April has a proliferative effect on both normal and tumor cell lines in vitro and in vivo. APRIL seems to be involved in the regulation of death and proliferation of tumor cells, but there are still contradictory findings regarding its overall biological effects.Recombinant mouse A Proliferation-inducing Ligand (rmApril) produced in E. coli is a single non-glycosylated polypeptide chain containing 192 amino acids. A fully biologically active molecule, rmApril has a molecular mass of 21.9 kDa analyzed by reducing SDS-PAGE.
Synonyms: A proliferating-inducing ligand, TNFSF13, TRDL-1 alpha.

Molekulargewicht: 21.9 kDa, observed by reducing SDS-PAGE.

UniProt: Q9D777

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response