PFKFB1 Protein (AA 2-471) (His tag)

Produktnummer ABIN1945453

Produktdetails

Target: PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 2-471

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses PFKFB1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Fructose-2,6-Bisphosphatase 1/PFKFB1/PFK/FBPase 1 (C-6His)

Sequenz: SPEMGELTQT RLQKIWIPHS SGSSRLQRRR GSSIPQFTNS PTMVIMVGLP ARGKTYISTK LTRYLNWIGT PTKVFNLGQY RREAVSYKNY EFFLPDNMEA LQIRKQCALA ALKDVHNYLS HEEGHVAVFD ATNTTRERRS LILQFAKEHG YKVFFIESIC NDPGIIAENI RQVKLGSPDY IDCDREKVLE DFLKRIECYE VNYQPLDEEL DSHLSYIKIF DVGTRYMVNR VQDHIQSRTV YYLMNIHVTP RSIYLCRHGE SELNIRGRIG GDSGLSVRGK QYAYALANFI QSQGISSLKV WTSHMKRTIQ TAEALGVPYE QWKALNEIDA GVCEEMTYEE IQEHYPEEFA LRDQDKYRYR YPKGESYEDL VQRLEPVIME LERQENVLVI CHQAVMRCLL AYFLDKSSDE LPYLKCPLHT VLKLTPVAYG CKVESIYLNV EAVNTHREKP ENVDITREPE EALDTVPAHY VDHHHHHH

Produktmerkmale: Recombinant Human PFKFB1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (AA 2-471) of Human PFKFB1 fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: -80 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: PFKFB1 (6-phosphofructo-2-Kinase/fructose-2,6-Biphosphatase 1 (PFKFB1))

Andere Bezeichnung: PFKFB1 (PFKFB1 Produkte)

Synonyme: zgc:55328 Protein, wu:fi11h10 Protein, PFKFB1 Protein, F6PK Protein, HL2K Protein, PFRX Protein, Pfkfb01 Protein, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 Protein, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 S homeolog Protein, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Protein, pfkfb1 Protein, PFKFB1 Protein, pfkfb1.S Protein, LOC100475853 Protein, Pfkfb1 Protein

Hintergrund: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 is an enzyme that in humans is encoded by the PFKFB1 gene. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. It belongs to the phosphoglycerate mutase family. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis.

Molekulargewicht: 55.6 kDa

UniProt: P16118

Pathways: Regulation of Carbohydrate Metabolic Process