ESAM Protein (AA 30-247) (Fc Tag)

Produktnummer ABIN1691594

Produktdetails

Target: ESAM (Endothelial Cell Adhesion Molecule (ESAM))

Protein-Typ: Recombinant

Proteineigenschaft: AA 30-247

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses ESAM Protein ist gelabelt mit Fc Tag.

Verwendungszweck: Recombinant Human Endothelial Cell Adhesion Molecule/ESAM (C-Fc)

Sequenz: QLQLHLPANR LQAVEGGEVV LPAWYTLHGE VSSSQPWEVP FVMWFFKQKE KEDQVLSYIN GVTTSKPGVS LVYSMPSRNL SLRLEGLQEK DSGPYSCSVN VQDKQGKSRG HSIKTLELNV LVPPAPPSCR LQGVPHVGAN VTLSCQSPRS KPAVQYQWDR QLPSFQTFFA PALDVIRGSL SLTNLSSSMA GVYVCKAHNE VGTAQCNVTL EVSTGPGAVD DIEGRMDEPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSREEM TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK

Produktmerkmale:

Recombinant Human Endothelial Cell Adhesion Molecule/ESAM (C-Fc)

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: ESAM (Endothelial Cell Adhesion Molecule (ESAM))

Andere Bezeichnung: Endothelial Cell Adhesion Molecule/ESAM (ESAM Produkte)

Synonyme: ESAM Protein, sc:d0254 Protein, W117m Protein, 2310008D05Rik Protein, Esam1 Protein, endothelial cell adhesion molecule Protein, endothelial cell adhesion molecule a Protein, endothelial cell-specific adhesion molecule Protein, ESAM Protein, esama Protein, Esam Protein

Hintergrund: Recombinant Human Endothelial Cell Adhesion Molecule/ESAM is produced by our mammalian expression system. The target protein is expressed with sequence (Gln30-Ala247) of Human ESAM fused with a FC tag at the C-terminus.
Endothelial Cell Adhesion Molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein member of the JAM family of immunoglobulin superfamily molecules. The 390 AA Human ESAM contains a 216 AA extracellular domain (ECD) with a V-type and a C2-type immunoglobulin (Ig) domain. ESAM is specifically expressed at endothelial tight junctions and on activated platelets and performs homophilic adhesion activity. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. In addition, ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. ESAM-deficient mice were described with lowered angiogenic potential, and accordingly, overexpression of ESAM is closely associated with certain tumor growth and metastasis. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes. The ECD of human and mouse ESAM share 69 % AA identity.

Molekulargewicht: 50.8 kDa

UniProt: Q96AP7