BMPR2 Protein (AA 27-151) (Fc Tag,His tag)

Produktnummer ABIN1691570

Produktdetails

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Protein-Typ: Recombinant

Proteineigenschaft: AA 27-151

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses BMPR2 Protein ist gelabelt mit Fc Tag,His tag.

Verwendungszweck: Recombinant Human BMP Receptor II/BMPR2/PPH1 (C-Fc-6His)

Sequenz: SQNQERLCAF KDPYQQDLGI GESRISHENG TILCSKGSTC YGLWEKSKGD INLVKQGCWS HIGDPQECHY EECVVTTTPP SIQNGTYRFC CCSTDLCNVN FTENFPPPDT TPLSPPHSFN RDETIVDDIE GRMDEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSREEMTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH

Produktmerkmale: Recombinant Human Bone morphogenetic protein receptor type-2/BMPR2/PPH1 is produced by our mammalian expression system. The target protein is expressed with sequence (Ser27-Ile151) of Human BMPR- II fused with FC and polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 5 months

Antigendetails

Target: BMPR2 (Bone Morphogenetic Protein Receptor, Type II (serine/threonine Kinase) (BMPR2))

Andere Bezeichnung: BMPR II (BMPR2 Produkte)

Synonyme: BMPR-II Protein, BMPR3 Protein, BMR2 Protein, BRK-3 Protein, PPH1 Protein, T-ALK Protein, 2610024H22Rik Protein, AL117858 Protein, AW546137 Protein, BB189135 Protein, BMP-2 Protein, BMPR-2 Protein, BMPRII Protein, Gm20272 Protein, Bmpr-II Protein, bmprii Protein, bone morphogenetic protein receptor type 2 Protein, bone morphogenetic protein receptor, type II b (serine/threonine kinase) Protein, bone morphogenetic protein receptor, type II (serine/threonine kinase) Protein, BMPR2 Protein, bmpr2b Protein, Bmpr2 Protein

Sub Type: Fusionprotein

Hintergrund: Bone Morphogenetic Protein Receptor II (BMPR-II) is a Type II Serine/Threonine Kinase that mediates cellular responses to BMPs. BMPR-II is characterized by lacking of a GS domain, and presence of a C-terminal extension typical of type II receptors. BMPRII binds BMP2, BMP4 and BMP7 weakly in the absence of type I receptor, and the binding can be facilitated by the presence of the type I receptor, including BMPR-IA/Brk1, BMPR-IB, and ActR-I. BMPR-II plays a key role in cell growth. Defects in BMPR-II have been linked to primary pulmonary hypertension. Human and mouse BMPR-II are highly conserved and share 97 % amino acid sequence identity.
Alternative Names: Bone Morphogenetic Protein Receptor Type-2, BMP Type-2 Receptor, BMPR-2, Bone Morphogenetic Protein Receptor Type II, BMP Type II Receptor, BMPR-II, BMPR2, PPH1

Molekulargewicht: 41.9 kDa

UniProt: Q13873

Pathways: Growth Factor Binding