HA2 Protein (His tag)

Produktnummer ABIN1686736

Produktdetails

Target: HA2 (H(+)-ATPase 2 (HA2))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses HA2 Protein ist gelabelt mit His tag.

Applikation: SDS-PAGE (SDS), Western Blotting (WB)

Spezifität: ~38 kDa

Aufreinigung: Affinity Purified

Reinheit: >90%

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

This product has been certified >90% pure using SDS - PAGE analysis.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: Lot specific

Buffer: 100 mM NaH2PO4 pH 4.5, 10 mM Tris buffer with 8M urea

Lagerung: -20 °C

Antigendetails

Target: HA2 (H(+)-ATPase 2 (HA2))

Andere Bezeichnung: Aha2 (HA2 Produkte)

Synonyme: AHA2 Protein, F9N11.40 Protein, F9N11_40 Protein, H(+)-ATPase 2 Protein, P-TYPE H(+)-ATPASE ISOFORM 2 Protein, PLASMA MEMBRANE PROTON ATPASE 2 Protein, PMA2 Protein, H[+]-ATPase 2 Protein, HA2 Protein

Hintergrund: Aha2 shares 45 % sequence homology with Aha1, however, little is known about the functional protein. Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).

Molekulargewicht: approx. 38 kDa

Gen-ID: 130872

NCBI Accession: NP_036243

UniProt: Q719I0

Pathways: Cellular Glucan Metabolic Process, Proton Transport