ESM1 Protein (His tag)

Produktnummer ABIN1589771

Produktdetails

Target: ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))

Protein-Typ: Recombinant

Spezies: Maus

Quelle: Insektenzellen

Aufreinigungstag / Konjugat: Dieses ESM1 Protein ist gelabelt mit His tag.

Sequenz: WSAKYAVDCP EHCDKTECRS SLRCKRTVLD DCGCCQVCAA GPGETCYRTV SGMDGVKCGP GLKCHFYSEE DDFGDEFGIC KDCPYGTFGM ECKETCNCQS GICDRVTGRC LDFPFFQYAA AKSPSRTSAS HTERDSASGD GNAVREEIGE GNAARPSVMK WLNPRTRHHH HHH

Produktmerkmale: Length (AA): 173
Chromosomal location: 13 D2.2, 13

Reinheit: > 95 % by SDS-PAGE. Visualized by silver stain

Anwendungsinformationen

Applikationshinweise: Not tested so far.

Kommentare:

Cytokines & Growth Factors

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Mouse Endocan/ESM-1 should be reconstituted in water to a concentration of 0.1 mg/mL. This solution can be diluted in water or other buffer solutions or stored at -20 °C.

Buffer: water

Lagerung: 0 °C

Informationen zur Lagerung: The lyophilized mouse Endocan/ESM-1, though stable at room temperature, is best stored desiccated below 0 °C.

Antigendetails

Target: ESM1 (Endothelial Cell-Specific Molecule 1 (ESM1))

Andere Bezeichnung: Endocan/ESM-1 (ESM1 Produkte)

Synonyme: ESM1 Protein, zgc:153027 Protein, 0610042H23Rik Protein, AV004503 Protein, ESM-1 Protein, Pg25 Protein, endocan Protein, endothelial cell specific molecule 1 Protein, endothelial cell-specific molecule 1 Protein, ESM1 Protein, esm1 Protein, Esm1 Protein

Hintergrund: Endocan, also known as endothelial cell-specific molecule1 (ESM1), is a secreted cysteine-rich dermatan sulfate (DS) proteoglycan primarily expressed by endothelial cells within the vascular capillary network in kidney and in the alveolar walls of the lung. Endocan expression has also been detected in different epithelia and in adipocytes. The expression of endocan is up-regulated by TNFα, IL1β or lipopolysaccharide and down-regulated by IFNγ. The human Endocan gene encodes a 184 amino acid (aa) residues precursor protein with a 19 aa hydrophobic signal peptide and a 165 aa mature region with 18 Cysteine residues. The DS chain is covalently attached to serine 137. Endocan has been shown to bind CD11a/CD18 integrin (also known as lymphocyte function-associated antigen1, LFA1) on human lymphocytes, monocytes and Jurkat cells, inhibiting its binding to ICAM1 and reducing LFA1mediated leukocyte activation. Endocan binds via its DS chain to hepatocyte growth factor (HGF) to enhance HGF mitogenic activity. Genetically engineered cells overexpressing Endocan has been shown to induce tumor formation, suggesting that Endocan may be involved in the pathophysiology of tumor growth in vivo. Circulating Endocan can be detected in the serum from healthy subjects. In patients with lung cancer or acute and severe sepsis, elevated Endocan concentrations have been reported.
Synonyms: Esm1, ESM-1, AV004503, 0610042H23Rik, endothelial cell-specific molecule 1

Molekulargewicht: 19.07 kDa

NCBI Accession: NM_023612, NP_076101

UniProt: Q9QYY7

Pathways: Growth Factor Binding