Ectodysplasin A Protein (EDA) (AA 240-391, Extracellular Domain, Soluble) (DYKDDDDK Tag)

Produktnummer ABIN1344402

Produktdetails

Target: Ectodysplasin A (EDA)

Protein-Typ: Recombinant

Proteineigenschaft: Soluble, Extracellular Domain, AA 240-391

Spezies: Maus, Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Ectodysplasin A Protein ist gelabelt mit DYKDDDDK Tag.

Applikation: SDS-PAGE (SDS)

Spezifität: Binds to human and mouse EDAR (ectodysplasin-A1 receptor).

Kreuzreaktivität: Human, Maus

Produktmerkmale: The extracellular domain of human EDA-A1 (aa 240-391) is fused at the N-terminus to a FLAG®-tag.

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.1EU/μg purified protein (LAL test, Lonza).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with 100 μL sterile water.

Konzentration: Lot specific

Buffer: Lyophilized. Contains PBS.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: Ectodysplasin A (EDA)

Andere Bezeichnung: EDA-A1 (EDA Produkte)

Synonyme: ECTD1 Protein, ED1 Protein, ED1-A1 Protein, ED1-A2 Protein, EDA-A1 Protein, EDA-A2 Protein, EDA1 Protein, EDA2 Protein, HED Protein, HED1 Protein, ODT1 Protein, STHAGX1 Protein, XHED Protein, XLHED Protein, si:ch73-223d24.5 Protein, Ed1 Protein, Eda-A1 Protein, Eda-A2 Protein, Ta Protein, tabby Protein, RGD1563178 Protein, ectodysplasin A Protein, ectodysplasin-A Protein, EDA Protein, eda Protein, Eda Protein

Hintergrund: The TNF family ligand ectodysplasin A (EDA) and its receptor EDAR are required for proper development of skin appendages such as hair, teeth, and eccrine sweat glands. Loss of function mutations in the Eda gene cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition that can be ameliorated in mice and dogs by timely administration of recombinant EDA. The Eda gene on the X chromosome is transcribed as multiple splice variants, only two of which code for the receptor-binding C-terminal TNF homology domain. These two variants code for 391- and 389-amino acid-long proteins called EDA1 and EDA2. EDA1 binds EDAR, whereas EDA2 binds to another receptor, XEDAR. The biology of EDA2 and XEDAR is distinct from that of EDA1. Indeed, XEDAR-deficient mice have no obvious ectodermal dysplasia phenotype, whereas mice deficient in EDA, EDAR, or the signaling adaptor protein EDARADD all display virtually indistinguishable ectodermal dysplasia phenotypes, indicating the predominance of the EDA1-EDAR axis in the development of skin-derived appendages.

Molekulargewicht: ~19kDa (SDS-PAGE)

UniProt: Q92838

Pathways: Tube Formation