LTA Protein
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- Target Alle LTA Proteine anzeigen
- LTA (Lymphotoxin-alpha (LTA))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Applikation
- ELISA, Functional Studies (Func)
- Marke
- BD Pharmingen™
- Spezifität
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Biological Activity: Bioactivity is tested in MTT/actinomycin D cytolysis assay using L929 indicator cells.
Specific Activity Range: 0.3 - 5.0x10^9 Unit /mg
ED50: 2 - 30 pg/ml
Observed dose response: > 500 fold
Unit is defined as the amount of material required to stimulate a half-maximal response at cytokine saturation. - Produktmerkmale
- Recombinant human LT-alpha is supplied as a frozen liquid comprised of 0.22 µm sterile-filtered Dulbecco’s PBS (pH 7.2) and containing biotechnology grade, low endotoxin bovine serum albumin, with no preservatives. The recombinant human LT-alpha is >95% pure as determined by SDS-PAGE analysis, and an absorbance assay based on the Beers-Lambert Law.
- Aufreinigung
- Recombinant human LT-α is supplied as a frozen liquid comprised of 0.22 μm sterile-filtered aqueous buffered solution, containing bovine serum albumin, with no preservatives. Recombinant human LT-α is ≥ 95 % pure as determined by SDS-PAGE analysis, and an absorbance assay based on the Beers-Lambert Law.
- Reinheit
- ≥ 95 %
- Sterilität
- 0.22 μm filtered
- Endotoxin-Niveau
- The endotoxin level is ≤ 0.1 ng per µg of LT-alpha, as measured in a chromogenic LAL assay.
- Top Product
- Discover our top product LTA Protein
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- Applikationshinweise
- ELISA Standard: This recombinant human LT-alpha is useful as a quantitative standard for measuring human LT-alpha protein levels in a LT-alpha specific sandwich ELISA with the purified 359-238-8 antibody (Cat. No. 551222) as a capture antibody and the biotinylated 359-81-11 antibody (Cat. No. 554555) as the detection antibody.
- Kommentare
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BD Pharmingen™ Recombinant Human LT-α - Reactivity Hu
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 200 μg/mL
- Buffer
- Frozen aqueous buffered solution containing BSA.
- Handhabung
- Lymphotoxin (LT-α), also known as, Tumor Necrosis Factor-β (TNF-β) is a potent multifunctional cytokine which is primarily produced by activated lymphocytes. LT-α has cytotoxic activity against a wide range of tumor cells and certain other target cells. Other LT-α activities include the activation of neutrophils, osteoclasts, and endothelial cells and the upregulation of the membrane expression of MHC antigens and adhesion molecules by various cell types. Human LT-α is a 18 kDa protein containing 171 amino acid residues.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Store product at -80°C prior to use or for long term storage of stock solutions. Rapidly thaw and quick-spin product prior to use. Avoid multiple freeze-thaws of product. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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Lymphotoxin." in: Annual review of immunology, Vol. 6, pp. 407-38, (1988) (PubMed).
: "
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Lymphotoxin." in: Annual review of immunology, Vol. 6, pp. 407-38, (1988) (PubMed).
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- Target
- LTA (Lymphotoxin-alpha (LTA))
- Andere Bezeichnung
- LT-alpha (LTA Produkte)
- Synonyme
- LT Protein, TNFB Protein, TNFSF1 Protein, LT-[a] Protein, LT-alpha Protein, LT[a] Protein, LTalpha Protein, Ltx Protein, TNF-beta Protein, Tnfb Protein, Tnfsf1b Protein, hlb382 Protein, lymphotoxin alpha Protein, lymphotoxin A Protein, LTA Protein, Lta Protein
- Substanzklasse
- Chemical
- Hintergrund
- Lymphotoxin (LT-α), also known as, Tumor Necrosis Factor-β (TNF-β) is a potent multifunctional cytokine which is primarily produced by activated lymphocytes. LT-α has cytotoxic activity against a wide range of tumor cells and certain other target cells. Other LT-α activities include the activation of neutrophils, osteoclasts, and endothelial cells and the upregulation of the membrane expression of MHC antigens and adhesion molecules by various cell types. Human LT-α is a 18 kDa protein containing 171 amino acid residues.
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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