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UBE2G2 Protein (AA 1-165) (GST tag)

UBE2G2 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Produktnummer ABIN1097730
  • Target Alle UBE2G2 Proteine anzeigen
    UBE2G2 (Ubiquitin-Conjugating Enzyme E2G 2 (UBE2G2))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 1-165
    Spezies
    • 8
    • 1
    Human
    Quelle
    • 4
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses UBE2G2 Protein ist gelabelt mit GST tag.
    Verwendungszweck
    Recombinant Human Ubiquitin-Conjugating Enzyme E2 G2/UBE2G2/UBC7 (N-GST)
    Sequenz
    MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD LVPRGSHMAG TALKRLMAEY KQLTLNPPEG IVAGPMNEEN FFEWEALIMG PEDTCFEFGV FPAILSFPLD YPLSPPKMRF TCEMFHPNIY PDGRVCISIL HAPGDDPMGY ESSAERWSPV QSVEKILLSV VSMLAEPNDE SGANVDASKM WRDDREQFYK IAKQIVQKSL GL
    Produktmerkmale

    Recombinant Human Ubiquitin-Conjugating Enzyme E2 G2/UBE2G2/UBC7 (N-GST)

    Reinheit
    > 95 % as determined by reducing SDS-PAGE.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test
    Top Product
    Discover our top product UBE2G2 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Rekonstitution
    It is not recommended to reconstitute to a concentration less than 100 μg/mL.
    Dissolve the lyophilized protein in ddH2O.
    Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
    Buffer
    Supplied as a 0.2 μm filtered solution of 50 mM HEPES, 150 mM NaCl, 2 mM DTT, 10 % Glycerol, pH 7.5.
    Konservierungsmittel
    Dithiothreitol (DTT)
    Vorsichtsmaßnahmen
    This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Store at < -20°C, stable for 6 months after receipt.
    Please minimize freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Target
    UBE2G2 (Ubiquitin-Conjugating Enzyme E2G 2 (UBE2G2))
    Andere Bezeichnung
    Ubiquitin-Conjugating Enzyme E2 G2/UBE2G2 (UBE2G2 Produkte)
    Synonyme
    UBC7 Protein, 1110003O05Rik Protein, D10Xrf369 Protein, Ubc7p Protein, wu:fu51c05 Protein, wu:fu56g11 Protein, zgc:112077 Protein, ubc7 Protein, ube2g1 Protein, ube2g2 Protein, wu:fi33c04 Protein, zgc:55974 Protein, ubiquitin conjugating enzyme E2 G2 Protein, ubiquitin-conjugating enzyme E2G 2 Protein, ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) Protein, ubiquitin-conjugating enzyme E2 G2 Protein, Ubiquitin-conjugating enzyme E2 G2 Protein, ubiquitin conjugating enzyme E2 G2 L homeolog Protein, ubiquitin-conjugating enzyme E2G 1a (UBC7 homolog, yeast) Protein, UBE2G2 Protein, Ube2g2 Protein, ube2g2 Protein, EDI_023910 Protein, CpipJ_CPIJ018658 Protein, Bm1_47630 Protein, ube2g2.L Protein, ube2g1a Protein
    Hintergrund
    Recombinant Human Ubiquitin-Conjugating Enzyme E2 G2/UBE2G2 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Leu165) of Human UBE2G2 fused with a GST tag at the N-terminus.
    Ubiquitin-Conjugating Enzyme E2 G2 (UBE2G2) is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation, which belong to the ubiquitin-conjugating enzyme family. It shares 60 % and 100 % sequence identity with S.cerevisiae Ubc7 and mouse respectively. The UBE2G2 enzyme and the GP78 E3 ligase are active components of endoplasmic reticulum-associated degradation pathway which is essential for the degradation of misfolded ER proteins. The mechanism of K48-linked poly-ubiquitination by UBE2G2/GP78 appears to involve the transfer of preassembled Ub chains from UBE2G2 to lysine residues in a substrate. The E2 and E3 enzymes form a large hetero-oligomer which brings multiple UBE2G2 molecules into close proximity which allows for Ub transfer between neighboring E2s.
    Molekulargewicht
    45 kDa
    UniProt
    P60604
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