SERPINA5 Protein (AA 20-406) (His tag)

Produktnummer ABIN1097511

Produktdetails

Target: SERPINA5 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 (SERPINA5))

Protein-Typ: Recombinant

Proteineigenschaft: AA 20-406

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses SERPINA5 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Serpin A5/Protein C Inhibitor (C-6His)

Sequenz: HRHHPREMKK RVEDLHVGAT VAPSSRRDFT FDLYRALASA APSQNIFFSP VSISMSLAML SLGAGSSTKM QILEGLGLNL QKSSEKELHR GFQQLLQELN QPRDGFQLSL GNALFTDLVV DLQDTFVSAM KTLYLADTFP TNFRDSAGAM KQINDYVAKQ TKGKIVDLLK NLDSNAVVIM VNYIFFKAKW ETSFNHKGTQ EQDFYVTSET VVRVPMMSRE DQYHYLLDRN LSCRVVGVPY QGNATALFIL PSEGKMQQVE NGLSEKTLRK WLKMFKKRQL ELYLPKFSIE GSYQLEKVLP SLGISNVFTS HADLSGISNH SNIQVSEMVH KAVVEVDESG TRAAAATGTI FTFRSARLNS QRLVFNRPFL MFIVDNNILF LGKVNRPVDH HHHHH

Produktmerkmale: Recombinant Human Serpin A5 produced by transfected human cells is a secreted protein with sequence (His20-Pro406) of Human SERPINA5 fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM MES, 150 mM NaCl, pH 5.5.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 3 months

Antigendetails

Target: SERPINA5 (serpin Peptidase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 (SERPINA5))

Andere Bezeichnung: protein-c-inhibitor (SERPINA5 Produkte)

Synonyme: 4933415L04 Protein, PAI-3 Protein, Pci Protein, PAI3 Protein, PCI Protein, PCI-B Protein, PLANH3 Protein, PROCI Protein, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 Protein, serpin family A member 5 Protein, serine (or cysteine) peptidase inhibitor, clade A, member 5 Protein, plasma serine protease inhibitor Protein, SPIA5 Protein, SERPINA5 Protein, Serpina5 Protein, LOC480424 Protein

Sub Type: Fusionprotein

Hintergrund: Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to Serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.
Alternative Names: Plasma Serine Protease Inhibitor, Acrosomal Serine Protease Inhibitor, Plasminogen Activator Inhibitor 3, PAI-3, PAI3, Protein C Inhibitor, PCI, Serpin A5, SERPINA5, PCI, PLANH3, PROCI

Molekulargewicht: 44.7 kDa

UniProt: P05154