RTN4RL1 Protein (AA 25-419) (His tag)

Produktnummer ABIN1097230

Produktdetails

Target: RTN4RL1 (Reticulon 4 Receptor-Like 1 (RTN4RL1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 25-419

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses RTN4RL1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Nogo-66 Receptor-Related 3/NgR3/RTN4RL1 (C-6His)

Sequenz: CPRDCVCYPA PMTVSCQAHN FAAIPEGIPV DSERVFLQNN RIGLLQPGHF SPAMVTLWIY SNNITYIHPS TFEGFVHLEE LDLGDNRQLR TLAPETFQGL VKLHALYLYK CGLSALPAGV FGGLHSLQYL YLQDNHIEYL QDDIFVDLVN LSHLFLHGNK LWSLGPGTFR GLVNLDRLLL HENQLQWVHH KAFHDLRRLT TLFLFNNSLS ELQGECLAPL GALEFLRLNG NPWDCGCRAR SLWEWLQRFR GSSSAVPCVS PGLRHGQDLK LLRAEDFRNC TGPASPHQIK SHTLTTTDRA ARKEHHSPHG PTRSKGHPHG PRPGHRKPGK NCTNPRNRNQ ISKAGAGKQA PELPDYAPDY QHKFSFDIMP TARPKRKGKC ARRTPIRAPS GVQQAVDHHH HHH

Produktmerkmale: Recombinant Human Nogo-66 Receptor-Related Protein 3/NgR3 produced by transfected human cells is a secreted protein with sequence (Cys25-Ala419) of Human RTN4RL1 fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 5 % Threhalose, pH 7.2.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 3 months

Antigendetails

Target: RTN4RL1 (Reticulon 4 Receptor-Like 1 (RTN4RL1))

Andere Bezeichnung: ngr3 (RTN4RL1 Produkte)

Synonyme: NgRH2a Protein, rtn4rl1 Protein, RTN4RL1 Protein, MGC146480 Protein, Ngr3 Protein, Ngrh2 Protein, Ngrl2 Protein, NGRH2 Protein, NgR3 Protein, reticulon 4 receptor-like 1b Protein, reticulon 4 receptor like 1 Protein, reticulon 4 receptor-like 1 Protein, rtn4rl1b Protein, RTN4RL1 Protein, rtn4rl1 Protein, Rtn4rl1 Protein

Sub Type: Fusionprotein

Hintergrund: Nogo-66 Receptor-Related Protein 3 (NgR3) has primary structures with NgR2 (NgRH1, NgRL3) and biochemical properties that are homologous to Nogo-66 receptor (NgR), and constitute a novel neuronal receptor protein family. NgR is GPI-anchored and contains eight leucine-rich repeats (LRR), it is the neuronal receptor for the myelin- associated proteins Nogo-A, OMgp (oligodendrocyte myelin glycoprotein), and MAG (myelin-associated glycoprotein) and mediates the inhibition of CNS axonal regeneration both in vitro and in vivo. NgR2 and NgR3 have similar structure and distinct but overlapping expression versus NgR. NgR2 can be metalloproteinase-cleaved to release a soluble ectodomain. NgR2 has also been shown to bind MAG, but ligands for NgR3 have not yet been determined. Mature huaman NgR3 shares 88%, 88%, 48% and 44% amino acid identity with mature mouse NgR3, rat NgR3, human NgRH1 and NgR, repectively.
Alternative Names: Reticulon-4 Receptor-Like 1, Nogo Receptor-Like 2, Nogo-66 Receptor Homolog 2, Nogo-66 Receptor-Related Protein 3, NgR3, RTN4RL1, NGRH2, NGRL2

Molekulargewicht: 45.49 kDa

UniProt: Q86UN2