CLIC4 Protein (AA 1-253) (His tag)

Produktnummer ABIN1096389

Produktdetails

Target: CLIC4 (Chloride Intracellular Channel 4 (CLIC4))

Protein-Typ: Recombinant

Proteineigenschaft: AA 1-253

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses CLIC4 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human Chloride Intracellular Channel Protein 4/CLIC4 (N-6His)

Sequenz: MGSSHHHHHH SSGLVPRGSH MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV VFSVTTVDLK RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC PPKYLKLSPK HPESNTAGMD IFAKFSAYIK NSRPEANEAL ERGLLKTLQK LDEYLNSPLP DEIDENSMED IKFSTRKFLD GNEMTLADCN LLPKLHIVKV VAKKYRNFDI PKEMTGIWRY LTNAYSRDEF TNTCPSDKEV EIAYSDVAKR LTK

Produktmerkmale: Recombinant Human Chloride Intracellular Channel Protein 4/CLIC4 produced by E. coli expression system. The target protein is expressed with sequence (Met1-Lys253) of Human CLIC4 fused with a 6His tag at the N-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM TrisHCl, 100 mM NaCl, 1 mM DTT, pH 8.0.

Konservierungsmittel: Dithiothreitol (DTT)

Vorsichtsmaßnahmen: This product contains Dithiothreitol (DTT): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: -80 °C

Informationen zur Lagerung: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Haltbarkeit: 6 months

Antigendetails

Target: CLIC4 (Chloride Intracellular Channel 4 (CLIC4))

Andere Bezeichnung: Chloride Intracellular Channel Protein 4/CLIC4 (CLIC4 Produkte)

Synonyme: CLIC4L Protein, H1 Protein, MTCLIC Protein, huH1 Protein, p64H1 Protein, cb142 Protein, wu:fb33c05 Protein, wu:fc30h10 Protein, clic4 Protein, MGC89006 Protein, CLIC4 Protein, DKFZp459A0325 Protein, D0Jmb3 Protein, TU-74 Protein, mc3s5 Protein, mtCLIC Protein, xclic4 Protein, chloride intracellular channel 4 Protein, chloride intracellular channel 4 (mitochondrial) Protein, chloride intracellular channel 4 S homeolog Protein, CLIC4 Protein, Clic4 Protein, clic4 Protein, clic4.S Protein

Sub Type: Fusionprotein

Hintergrund: Chloride Intracellular Channel Protein 4 (CLIC4) is a 253 amino acid single-pass membrane protein that localizes to both the nucleus and the cytoplasm and contains one GST C-terminal domain. CLIC4 is expressed in various tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). CLIC4 acts as a monomer which is able to form selective ion channels in target proteins, thus facilitating the transport of chloride and other ions. CLIC4 is believed to have a role in apoptosis and is able to translocate to the nucleus under stress conditions. CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis.
Alternative Names: Chloride Intracellular Channel Protein 4, Intracellular Chloride Ion Channel Protein p64H1, CLIC4

Molekulargewicht: 30.9 kDa

UniProt: Q9Y696