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the data presented here suggest that CEA (zeige CEACAM5 Proteine) promoter-targeted exogenous RPL23 (zeige RPL17 Proteine) expression could be of therapeutic value against human colorectal carcinoma that retains wt-p53 (zeige TP53 Proteine).
the data presented here demonstrate that co-transduction of RPL23 (zeige RPL17 Proteine) enhances the therapeutic efficacy of adenoviral-mediated p53 (zeige TP53 Proteine) gene transfer in models of human gastric cancer and support the use of this strategy for cancer treatment.
L23 is a novel oncogene (zeige RAB1A Proteine) in the squamous cell carcinoma of the head and neck
Increased RPL23 (zeige RPL17 Proteine) expression is found in patients with higher-risk myelodysplastic syndrome (MDS (zeige PAFAH1B1 Proteine)) than in patients with lower-risk disease.
either RPS13 (zeige RPS13 Proteine) or RPL23 (zeige RPL17 Proteine) can promote MDR in gastric cancer cells by suppressing drug-induced apoptosis, and RPL23 (zeige RPL17 Proteine) may also promote MDR in gastric cancer cells through regulation of glutathione S-transferase (zeige GSTa2 Proteine)-mediated drug-detoxifying system
the MDM2 (zeige MDM2 Proteine)-L5-L11 (zeige RPL11 Proteine)-L23 complex functions to inhibit MDM2 (zeige MDM2 Proteine)-mediated p53 (zeige TP53 Proteine) ubiquitination and thus activates p53 (zeige TP53 Proteine)
These results reveal that ribosomal protein L23 is another regulator of the p53 (zeige TP53 Proteine)-MDM2 (zeige MDM2 Proteine) feedback regulation involved in cell growth.
Data show that, when overexpressed, ribosomal protein L23 inhibits HDM2-induced p53 (zeige TP53 Proteine) polyubiquitination and degradation and causes a p53 (zeige TP53 Proteine)-dependent cell cycle arrest.
The ribosomal protein L23 is a negative regulator of Miz1 (zeige ZBTB17 Proteine)-dependent transactivation.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae\; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
60S ribosomal protein L17
, 60S ribosomal protein L23
, ribosomal protein L17
, ribosomal protein L17A
, ribosomal protein L23
, ribosomal protein L23 L homeolog