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Authors demonstrated that ER(alpha (zeige ESR1 Antikörper)), GATA3 (zeige GATA3 Antikörper) and FOXA1 (zeige FOXA1 Antikörper) form a transcriptional complex with Ell3 (zeige ELL3 Antikörper) to regulate IL-20 expression in ER(+) breast cancer cells. FOXA1 (zeige FOXA1 Antikörper) represses IL-20 expression, whereas GATA3 (zeige GATA3 Antikörper) and ER(alpha (zeige ESR1 Antikörper)) activate it.
The authors results indicate that genetic variants of the immunomodulatory IL10 (zeige IL10 Antikörper) and IL20 genes may offer a protective effect in Europeans from Russia.
data showed that IL-20 is independently associated with rheumatoid arthritis disease activity and may be triggered by TLR ligands at local sites of inflammation
IL-20 is a multifunctional cytokine with potent inflammatory, angiogenic, chemoattractive, and osteoclastogenic effects, and is involved in the many phases of rheumatic arthritis progression. [Review]
IL-20 and IL-24 (zeige IL24 Antikörper) increased the production of monocyte chemoattractant protein-1 (zeige CCL2 Antikörper) by activated spondyloarthritis synovial fluid monocytes, decreased the production of Dickkopf-1 (zeige DKK1 Antikörper) by SpA (zeige FASL Antikörper) fibroblast-like synovial cells and induced mineralization in human osteoblasts; taken together, findings indicate disease-aggravating functions of IL-20 and IL-24 (zeige IL24 Antikörper) in spondyloarthritis
Data suggest that HGF (zeige HGF Antikörper), IL-20, and IL-22 (zeige IL22 Antikörper) in the serum and bronchoalveolar lavage fluid (BALF) of non-small cell lung cancer (NSCLC) patients before chemotherapy may be a prognostic of cancer progression.
The current study provides evidence that IL-20 directly targets and inhibits key inflammatory functions of neutrophils during infection with S. aureus.
Results found that IL-20 is more specifically associated with ER-positive breast cancer and is epigenetically regulated by estrogen via the specific recruitment of KMT2B (zeige MLL2 Antikörper) by ERalpha (zeige ESR1 Antikörper).
Coincident diabetes mellitus type 2 in either pulmonary or latent tuberculosis is characterized by decreased production of the IL-20 subfamily of cytokines.
IL-20 serum levels were increased in patients with active multiple myeloma compared to both healthy controls and responders to bortezomib-based treatment.IL-20 participate actively in the pathophysiology of multiple myeloma progression.
our data suggest that IL-20 subfamily cytokines, particularly IL-20, IL-22 (zeige IL22 Antikörper), and IL-24 (zeige IL24 Antikörper), might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) .
The authors conclude that IL-20 affects bone formation and downregulates osteoblastogenesis by modulating sclerostin (zeige SOST Antikörper), osterix (zeige SP7 Antikörper), RUNX2 (zeige RUNX2 Antikörper), and osteoprotegerin (zeige TNFRSF11B Antikörper) on osteoblasts.
Data show that interleukin 20 (IL-20) is expressed in type 2 diabetic db/db (zeige LEPR Antikörper) islets and contributes to inflammation.
IL-20 is primarily up regulated in psoriatic skin at the post-transcriptional level.
our results suggest that IL-20 plays pivotal roles in the tumor progression of breast cancer. IL-20 expression in breast cancer tissue is associated with a poor clinical outcome.
IL-20 is a proatherogenic cytokine that contributes to the progression of atherosclerosis.
IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs
novel effects of IL-20 on mesangial cells and its association with lupus nephritis.
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.
, four alpha helix cytokine
, four alpha helix cytokine ZCYTO10
, four helix bundle cytokine 10
, interleukin 20