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Upregulation of FOXM1 in a subset of relapsed myeloma results in poor outcome.
We first reported that the FOMX1 pathway is the most upregulated and the PPARalpha (zeige PPARA Proteine) pathway is the most downregulated pathway in Triple Negative Breast Cancers (TNBCs). These two pathways could be simultaneously targeted in further studies. Also the pathway classifier we performed in this study provided insight into the TNBC heterogeneity.
FOXM1 and ABCG2 may be useful targets and important parameters in the treatment of bladder cancer.
FOXM1 is a highly prognostic marker for disease progression.
Study found that FOXM1 is a target of miR (zeige MLXIP Proteine)-149. miR (zeige MLXIP Proteine)-149 inhibited FOXM1 mRNA and protein expression levels by binding to its 3'-UTR in non-small cell lung cancer (NSCLC) cells. Moreover, patients with low expression levels of miR (zeige MLXIP Proteine)-149 exerted high FOXM1 mRNA levels.
we found that FOXM1 inhibitor attenuated tumorigenesis and radioresistance of glioblastoma (GBM) both in vitro and in vivo. Altogether, BUB1B (zeige BUB1B Proteine) promotes tumor proliferation and induces radioresistance in GBM, indicating that BUB1B (zeige BUB1B Proteine) could be a potential therapeutic target for GBM.
MYBL2 (zeige MYBL2 Proteine) is a key downstream factor of Akt (zeige AKT1 Proteine)/FoxM1 signaling to promote progression of human glioma, and could be a new candidate gene for molecular targeting therapy and biomarker for radiotherapy of glioma.
FoxM1 may enhance the invasion and migration of cancer cells, and thus promotes their Epithelialmesenchymal transition, in a mechanism that may involve the regulation of Snai1 (zeige SNAI1 Proteine).
FoxM1 promotes glioma progression by enhancing UBE2C (zeige UBE2C Proteine) transcription
We found that, compared with the control, the proliferative, migratory and invasive abilities of PC-3 (zeige PCSK1 Proteine) cells were decreased after incubation with different concentrations of TMP . The expression of FOXM1 was decreased in TMP-treated PC-3 (zeige PCSK1 Proteine) cells
Upregulated ROS (zeige ROS1 Proteine) induced by FABP4 (zeige FABP4 Proteine) was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.
Interactions between the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and the Kras/ERK (zeige EPHB2 Proteine)/Foxm1 pathways are essential to restrict SOX9 (zeige SOX9 Proteine) expression in basal cells during pulmonary branching morphogenesis
YAP (zeige YAP1 Proteine) cooperates with FOXM1 to contribute to chromosome instability in hepatocellular carcinoma.
RCM-1 (zeige TNNI3 Proteine) blocked the nuclear localization and increased the proteasomal degradation of Forkhead box M1 (FOXM1), a transcription factor critical for the differentiation of goblet cells from airway progenitor cells.
These data implicate the insulin (zeige INS Proteine)-FoxM1/PLK1/CENP-A (zeige CENPA Proteine) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
EGF (zeige EGF Proteine) promotes FoxM1 expression through the ERK (zeige EPHB2 Proteine) signal pathway
FoxM1 induction in the pulmonary vasculature was inhibited by a p110gamma (zeige PIK3CG Proteine)-selective inhibitor and in Pik3cg (zeige PIK3CG Proteine)(-/-) mice after LPS (zeige TLR4 Proteine) challenge. Defective vascular repair in Pik3cg (zeige PIK3CG Proteine)-/- mice results from impaired FoxM1 expression
we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 (zeige HOXA10 Proteine) and cyclin D3 (zeige CCND3 Proteine).
FOXM1 and CENPF (zeige CENPF Proteine) are master regulators of prostate cancer malignancy, and can serve as drug response markers for antineoplastic drugs efficiency.
Both gain-of-function and loss-of-function TP53 (zeige TP53 Proteine) mutations contribute to overexpression of FoxM1 in high-grade serous ovarian cancer.
the sequence and expression pattern of FoxM1 (fork head box M1) transcription factor in Xenopus laevis embryos are described
Results suggest that FoxM1 functions to link cell division and neuronal differentiation in early Xenopus embryos.
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
Forkhead, drosophila, homolog-like 16
, HNF-3/fork-head homolog 11
, M-phase phosphoprotein 2
, MPM-2 reactive phosphoprotein 2
, forkhead box protein M1
, forkhead-related protein FKHL16
, hepatocyte nuclear factor 3 forkhead homolog 11
, transcription factor Trident
, winged-helix factor from INS-1 cells
, INS-1 winged helix
, forkhead box M1
, forkhead box protein M1-like
, forkhead homolog 16
, winged-helix transcription factor Trident