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NF-kappaB (zeige NFKB1 Proteine) physically interacts with FOXM1 and promotes transcription of FOXM1 gene. NF-kappaB (zeige NFKB1 Proteine) directly binds FOXM1 gene promoter. Silencing p65 (zeige GORASP1 Proteine) attenuates FOXM1 and beta-catenin (zeige CTNNB1 Proteine) expression. NF-kappaB (zeige NFKB1 Proteine) activation is required for nuclear translocation of FOXM1 and beta-catenin (zeige CTNNB1 Proteine). FOXM1 and beta-catenin (zeige CTNNB1 Proteine) positively regulate NF-kappaB.Knockdown of beta-catenin (zeige CTNNB1 Proteine) and FOXM1 downregulates p65 (zeige GORASP1 Proteine) protein and NF-kappaB (zeige NFKB1 Proteine)-dependent reporte...
FOXM1 expression in solid tumor tissues is associated with poor survival in most solid tumors, which suggests that FOXM1 is a valuable prognostic biomarker and a promising therapeutic target for solid tumors.
FOXM1 is up-regulated in all three major EOCs subtypes, and is a prognostic biomarker and a potential combinatorial therapeutic target in platinum resistant disease, irrespective of tumor histology.
Authors demonstrated that inhibition of either FOXM1 or AGR2 (zeige AGR2 Proteine) in human PIMAs inhibited mucinous characteristics, and reduced tumor growth and invasion. FOXM1 is necessary and sufficient to induce mucinous phenotypes in lung tumor cells in vivo.
we hypothesize that FOXM1 regulates radioresistance via STAT3 (zeige STAT3 Proteine) in GBM cells. We also, show GBM patients with high FOXM1 expression have poor prognosis.
FOXM1 promotes 5-FU resistance by up-regulating ABCC10 (zeige ABCC10 Proteine) expression in colorectal tumor cells.
Findings provide a novel understanding of the mechanism of gastric cancer and highlight the important role of BTF3 (zeige BTF3 Proteine)/FOXM1 in tumor growth and BTF3 (zeige BTF3 Proteine)/JAK2 (zeige JAK2 Proteine)/STAT3 (zeige STAT3 Proteine) in EMT (zeige ITK Proteine) and metastasis
FOXM1 bound directly to the GLUT1 (zeige SLC2A1 Proteine) and HK2 (zeige HK2 Proteine) promoter regions and regulated the promoter activities and the expression of the genes at the transcriptional level. This reveals a novel mechanism by which glucose metabolism is regulated by FOXM1.
Gli1 (zeige GLI1 Proteine) promotes colorectal cancer cells metastasis in a Foxm1-dependent manner by activating EMT (zeige ITK Proteine) and PI3K (zeige PIK3CA Proteine)-AKT (zeige AKT1 Proteine) signaling.
we suggest that high glucose and elevated O-GlcNAcylation stabilize FOXM1 protein by its reduced degradation via GSK-3beta inactivation in MKN45 cells, suggesting that the higher risk of gastric cancer in diabetic patients could be partially due to O-GlcNAcylation-mediated FOXM1 stabilization
Upregulated ROS (zeige ROS1 Proteine) induced by FABP4 (zeige FABP4 Proteine) was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.
Interactions between the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and the Kras/ERK (zeige EPHB2 Proteine)/Foxm1 pathways are essential to restrict SOX9 (zeige SOX9 Proteine) expression in basal cells during pulmonary branching morphogenesis
YAP (zeige YAP1 Proteine) cooperates with FOXM1 to contribute to chromosome instability in hepatocellular carcinoma.
RCM-1 (zeige TNNI3 Proteine) blocked the nuclear localization and increased the proteasomal degradation of Forkhead box M1 (FOXM1), a transcription factor critical for the differentiation of goblet cells from airway progenitor cells.
These data implicate the insulin (zeige INS Proteine)-FoxM1/PLK1/CENP-A (zeige CENPA Proteine) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
EGF (zeige EGF Proteine) promotes FoxM1 expression through the ERK (zeige EPHB2 Proteine) signal pathway
FoxM1 induction in the pulmonary vasculature was inhibited by a p110gamma (zeige PIK3CG Proteine)-selective inhibitor and in Pik3cg (zeige PIK3CG Proteine)(-/-) mice after LPS (zeige TLR4 Proteine) challenge. Defective vascular repair in Pik3cg (zeige PIK3CG Proteine)-/- mice results from impaired FoxM1 expression
we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 (zeige HOXA10 Proteine) and cyclin D3 (zeige CCND3 Proteine).
FOXM1 and CENPF (zeige CENPF Proteine) are master regulators of prostate cancer malignancy, and can serve as drug response markers for antineoplastic drugs efficiency.
Both gain-of-function and loss-of-function TP53 (zeige TP53 Proteine) mutations contribute to overexpression of FoxM1 in high-grade serous ovarian cancer.
the sequence and expression pattern of FoxM1 (fork head box M1) transcription factor in Xenopus laevis embryos are described
Results suggest that FoxM1 functions to link cell division and neuronal differentiation in early Xenopus embryos.
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
forkhead box protein M1
, forkhead box M1
, forkhead box protein M1-like
, Forkhead, drosophila, homolog-like 16
, HNF-3/fork-head homolog 11
, M-phase phosphoprotein 2
, MPM-2 reactive phosphoprotein 2
, forkhead-related protein FKHL16
, hepatocyte nuclear factor 3 forkhead homolog 11
, transcription factor Trident
, winged-helix factor from INS-1 cells
, forkhead homolog 16
, winged-helix transcription factor Trident
, INS-1 winged helix