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High FOXM1 expression is associated with invasion of renal cancer.
Analyses with phospho-defective and phospho-mimetic mutants of FoxM1b identified a critical role of the Plk1 phosphorylation sites in regulating the binding of FoxM1b to Rb and DNMT3b (zeige DNMT3B Proteine).
Study found that DLX1 was the direct target of FoxM1 in HCC (zeige FAM126A Proteine). Downregulation of FoxM1 inhibits the proliferation, migration, and invasion of HCC (zeige FAM126A Proteine) cells by miR (zeige MLXIP Proteine)-214.
A significant over expression of forkhead box protein M1 (FOXM1), polo-like kinase 1 (PLK1) and centrosomal protein 55 (CEP55 (zeige CEP55 Proteine)) was observed in tumor samples compared to adjacent and normal bladder tissues, suggesting they may be potential candidate's biomarkers for early diagnosis and targets for cancer therapy.
In conclusion, our findings indicated that FOXM1 was highly expressed in lung cancer cells after exposure to ionizing radiation (IR). We also found that FOXM1 promoted radioresistance, invasion, migration, and EMT (zeige ITK Proteine) of lung cancer cells after IR, partly through upregulating KIF20A (zeige KIF20A Proteine).
The concurrent overexpression of FoxM1 and FoxP3 (zeige FOXP3 Proteine) was evident in gastric cancer and inversely correlated with patient survival.
A better understanding of the mechanisms regulating the FOXO3 (zeige FOXO3 Proteine)-FOXM1 axis, as well as their downstream transcriptional targets and functions, may render these proteins reliable and early diagnostic/prognostic factors as well as crucial therapeutic targets for cancer treatment and importantly, for overcoming chemotherapeutic drug resistance.
CRNDE overexpression accelerated lipopolysaccharide-induced apoptosis and inflammation via up-regulation of FOXM1 in WI-38 cells.
In male breast cancer patients high forkhead box protein M1 (FOXM) expression is significantly associated with disease free survival (DFS (zeige FST Proteine)). Median progression free survival under chemotherapy or Tamoxifen hormone therapy is shorter for the High FOXM1 expression group. High FOXM1 expression is significantly associated with chemotherapy and endocrine resistance.
High FoxM1 expression is associated with the development of prostate cancer.
Vagal signals activate the forkhead box M1 (FoxM1) pathway in beta-cells, resulting in compensatory beta-cell proliferation. Inducible beta-cell-specific FoxM1 deficiency also blocks compensatory beta-cell proliferation.
Disrupting LXRalpha (zeige NR1H3 Proteine) phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation
Upregulated ROS (zeige ROS1 Proteine) induced by FABP4 (zeige FABP4 Proteine) was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.
Interactions between the Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) and the Kras/ERK (zeige EPHB2 Proteine)/Foxm1 pathways are essential to restrict SOX9 (zeige SOX9 Proteine) expression in basal cells during pulmonary branching morphogenesis
YAP (zeige YAP1 Proteine) cooperates with FOXM1 to contribute to chromosome instability in hepatocellular carcinoma.
RCM-1 (zeige TNNI3 Proteine) blocked the nuclear localization and increased the proteasomal degradation of Forkhead box M1 (FOXM1), a transcription factor critical for the differentiation of goblet cells from airway progenitor cells.
These data implicate the insulin (zeige INS Proteine)-FoxM1/PLK1/CENP-A (zeige CENPA Proteine) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
EGF (zeige EGF Proteine) promotes FoxM1 expression through the ERK (zeige EPHB2 Proteine) signal pathway
FoxM1 induction in the pulmonary vasculature was inhibited by a p110gamma (zeige PIK3CG Proteine)-selective inhibitor and in Pik3cg (zeige PIK3CG Proteine)(-/-) mice after LPS (zeige TLR4 Proteine) challenge. Defective vascular repair in Pik3cg (zeige PIK3CG Proteine)-/- mice results from impaired FoxM1 expression
we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 (zeige HOXA10 Proteine) and cyclin D3 (zeige CCND3 Proteine).
the sequence and expression pattern of FoxM1 (fork head box M1) transcription factor in Xenopus laevis embryos are described
Results suggest that FoxM1 functions to link cell division and neuronal differentiation in early Xenopus embryos.
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
Forkhead, drosophila, homolog-like 16
, HNF-3/fork-head homolog 11
, M-phase phosphoprotein 2
, MPM-2 reactive phosphoprotein 2
, forkhead box protein M1
, forkhead-related protein FKHL16
, hepatocyte nuclear factor 3 forkhead homolog 11
, transcription factor Trident
, winged-helix factor from INS-1 cells
, INS-1 winged helix
, forkhead box M1
, forkhead box protein M1-like
, forkhead homolog 16
, winged-helix transcription factor Trident