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In summary, our data suggested that PYK2 (zeige PTK2B ELISA Kits) via S6K1 activation modulated AR function and growth properties in prostate cancer cells. Thus, PYK2 (zeige PTK2B ELISA Kits) and S6K1 may potentially serve as therapeutic targets for PCa (zeige FLVCR1 ELISA Kits) treatment.
Modulation of IL-2 (zeige IL2 ELISA Kits), IL-4 (zeige IL4 ELISA Kits), IFN-gamma (zeige IFNG ELISA Kits) and/or TNF-alpha (zeige TNF ELISA Kits) levels, or inhibitors of Erk1/2 (zeige MAPK1/3 ELISA Kits) or S6K1 may be a new approach to prevent BAFF (zeige TNFSF13B ELISA Kits)-induced aggressive B-cell malignancies.
Overexpression of AIM2 (zeige AIM2 ELISA Kits) in hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) cells suppressed mammalian target of rapamycin (mTOR (zeige FRAP1 ELISA Kits))-S6K1 pathway and further inhibited proliferation of HCC (zeige FAM126A ELISA Kits) cells.
Data show that ribosomal protein S6 (zeige RPS6 ELISA Kits) kinases, 70-kDa (p70S6K) and interleukin-6 (IL-6 (zeige IL6 ELISA Kits)) were upregulated in high-metastatic head and neck squamous cell carcinoma (HNSCC) cell lines that underwent epithelial-mesenchymal transition (EMT (zeige ITK ELISA Kits)) when compared to paired low-metastatic cell lines.
S6K plays a critical role in dopaminergic neuronal differentiation in human neural stem cells.
Elevated levels of p-Mnk1 (zeige MKNK1 ELISA Kits), p-eIF4E (zeige EIF4E ELISA Kits) and p-p70S6K proteins are associated with tumor recurrence and poor prognosis in astrocytomas. Overexpression of p-eIF4E (zeige EIF4E ELISA Kits) and co-expression of p-Mnk1 (zeige MKNK1 ELISA Kits), p-eIF4E (zeige EIF4E ELISA Kits) and p-p70S6K proteins could be used as novel independent poor prognostic biomarkers for patients with astrocytomas.
ULK1 (zeige ULK1 ELISA Kits) has a role in RPS6KB1-NCOR1 (zeige NCOR1 ELISA Kits) repression of NR1H/LXR (zeige NR1H3 ELISA Kits)-mediated Scd1 (zeige SCD ELISA Kits) transcription and augments lipotoxicity in hepatic cells
function mimicked by the viral protein kinase encoded by open reading frame 36 of Kaposi's sarcoma-associated herpesvirus
our data suggest that RPS6KB1 is over-activated as p-RPS6KB1 in non-small cell lung cancer, rather than just the total protein overexpressing. The phosphorylation level of RPS6KB1 might be used as a novel prognostic marker for NSCLC patients.
p54 (zeige DDX6 ELISA Kits)-S6K2 (zeige RPS6KB2 ELISA Kits) interactome is predominant to the nucleus, whereas p70-S6K1 is predominant to cytosol.
MYC (zeige MYC ELISA Kits) and S6K cooperate through coordinate activation of the essential Pol I transcription initiation factor TIF-1A (zeige RRN3 ELISA Kits).
This study showed that p70 S6 kinase (zeige PRKACB ELISA Kits) (S6k), acting downstream of the insulin receptor (InR (zeige INSR ELISA Kits)) and the small GTPase (zeige RACGAP1 ELISA Kits) Arf6 (zeige ARF6 ELISA Kits), is a key mediator of ethanol-induced sedation in Drosophila
our results indicate that S6K1 has an inhibitory effect on autophagic activity under normal nutritional conditions
S6 kinase localizes to the presynaptic active zone and functions with PDK1 (zeige PDPK1 ELISA Kits) to control synapse development
the effect of allelic variation at S6k on a range of phenotypes associated with metabolism and fitness in an age-, diet-, and sex-specific manner
Data show that female Drosophila melanogaster undergo a dietary switch following mating and that S6 kinase and serotonin production are involved in this switch.
Data show that mating status modulates food choice in females, that it relies on the action of the sex peptide receptor in sensory neurons, and that neuronal TOR/S6K function affects this decision, possibly signaling the fly's current nutritional status.
DHR3 (zeige ERCC2 ELISA Kits) modulates dS6 (zeige RPS6 ELISA Kits) kinase-dependent growth in Drosophila.
dS6K activity is dependent on the Drosophila homologue of the phosphoinositide-dependent protein kinase 1, dPDK1, demonstrating that both dPDK1, as well as dTOR, mediated dS6K activation is phosphatidylinositide-3,4,5-trisphosphate (PIP3)-independent.
Rheb (zeige RHEB ELISA Kits) is an essential regulator of S6K in controlling cell growth in Drosophila.
Activation of S6K1-mediated protein synthesis and increased autophagy in white adipose tissue was detected in chronic alcohol fed animals.
we show that simultaneous inhibition of mTOR (zeige FRAP1 ELISA Kits) signaling to both S6K1 and 4E-BP1 (zeige EIF4EBP1 ELISA Kits) is sufficient to reduce AKT (zeige AKT1 ELISA Kits)-induced muscle growth and render it insensitive to the mTORC1-inhibitor rapamycin
S6K1 acts through multiple targets of the mTOR (zeige FRAP1 ELISA Kits) pathway to promote self-renewal and leukemia progression
transfection of cells with a constitutively active rapamycin-resistant p70S6K mutant could restore the mineralizing capacity of HtrA1 (zeige HTRA1 ELISA Kits)-deficient mouse adipose-derived stromal cells.
We provide mechanistic evidence that S6K1's negative feedback to PI3K signaling is involved in axon growth inhibition, and show that phosphorylation of S6K1 is a more appropriate regeneration indicator than is S6 phosphorylation.
S6K1 phosphorylation of H2B mediates EZH2 (zeige EZH2 ELISA Kits) trimethylation of H3 early in adipogenesis, contributing to the promotion of obesity.
the p70S6K isoforms have unique and redundant functions in mediating fibrogenic processes, including proliferation, migration.
Rcan2 (zeige RCAN2 ELISA Kits) and Rps6kb1 mutations both affect growth and body weight of mice, though likely through different mechanisms
Findings indicate that similar to overall cell size growth, Golgi growth is modulated by the "cell growth checkpoint" at late G1 phase through the activities of S6 kinase 1 (S6K1).
the results identify the JNK (zeige MAPK8 ELISA Kits)/S6K1 axis as a key molecular mechanism whereby a high fat/sucrose diet impairs insulin (zeige INS ELISA Kits) action in retina.
data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (zeige AKT1 ELISA Kits), mTOR (zeige FRAP1 ELISA Kits), p70S6K, and ERK1/2 (zeige MAPK1/3 ELISA Kits).
Lys (zeige LYZ ELISA Kits), His, and Thr (zeige TRH ELISA Kits) inhibited S6K1 phosphorylation in bovine mammary cells
This study found that, early in rotavirus enteritis, arginine has no impact on diarrhea but augments intestinal protein synthesis in part by p70(S6k) stimulation.
There was no correlation of infarct size with expression or phosphorylation of p70S6K or GSK3beta (zeige GSK3b ELISA Kits) in ischemic postconditioning.
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17.
p70 S6 kinase, alpha
, ribosomal protein S6 kinase I
, ribosomal protein S6 kinase beta-1
, serine/threonine kinase 14 alpha
, serine/threonine-protein kinase 14A
, p70 S6 kinase
, S6 kinase
, dS6 kinase
, p70 ribosomal S6 kinase
, ribosomal S6 protein kinase
, ribosomal protein S6 kinase
, 70 kDa ribosomal protein S6 kinase 1
, p70 S6 kinase alpha
, p70 S6K-alpha
, p70 S6KA
, p70 ribosomal S6 kinase alpha
, p70-S6K 1
, ribosomal protein S6 kinase, 70kD, polypeptide 1
, ribosomal protein S6 kinase, 70kDa, polypeptide 1
, G3 serine/threonine kinase
, ribosomal protein S6 kinase polypeptide 1