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High genetic risk scores of SLIT3, PLEKHA5 and PPP2R2C variants increase susceptibility to increased insulin resistance by 50% and its risk may be exacerbated by consuming more than 10 cups coffee/week or 220 mg caffeine/day.
B55gamma is induced by glucocorticoid receptor in human primary BM-MSCs during differentiation to osteoblast and is required for osteoblast morphogenesis.
miR-572 promotes the proliferation and invasion of nasopharyngeal carcinoma by directly down-regulating PPP2R2C
miR-1301 promoted prostate cancer proliferation by inhibiting PPP2R2C.
These findings provide insights into mechanisms by which prostate cancers resist AR-pathway suppression and support inhibiting PPP2R2C complexes.
PPP2R2C is a potential tumor suppressor gene in human brain cancers.
evidence suggests that allelic variation in PPP2R2C may be associated with a variety of personality traits and ADHD per se.
encoding a subunit of proteinphosphatase 2A with a unique expression pattern in brain and a role in synaptic plasticity
specific PP2A complexes involved in human cell transformation
novel mechanism of c-SRC regulation whereby in response to stress c-SRC activity is regulated, at least in part, through loss of the interaction with its inhibitor, PR55gamma
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
PP2A subunit B isoform B55-gamma
, PP2A subunit B isoform PR55-gamma
, PP2A subunit B isoform R2-gamma
, PP2A subunit B isoform gamma
, serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
, PP2A, subunit B, B-gamma isoform
, PP2A, subunit B, B55-gamma isoform
, PP2A, subunit B, PR55-gamma isoform
, PP2A, subunit B, R2-gamma isoform
, gamma isoform of regulatory subunit B55, protein phosphatase 2
, phosphoprotein phosphatase 2A BR gamma regulatory chain
, protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
, protein phosphatase 2A1 B gamma subunit
, protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform
, PP2A subunit B isoform BRgamma
, PP2A, subunit B, BRgamma isoform