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these data demonstrate that miR (zeige MLXIP Proteine)-130b represses vascular inflammation via targeting Tpl2
Results show that the binding of miR (zeige MLXIP Proteine)-589-5p to the MAP3K8 3'-UTR inhibits MAP3K8 expression and suppresses CD90 (zeige THY1 Proteine)+ cancer stem cells characteristics in hepatocellular carcinoma.
RelAp43 interacts with the p105 (zeige CDH13 Proteine)-ABIN2 (zeige TNIP2 Proteine)-TPL2 complex and we observe a strong perturbation of this complex in presence of M protein (zeige MYOM2 Proteine).
miRNA-509-3p mimics or inhibitor transfection tests in KGN cells further confirmed that miRNA-509-3p improved oestradiol (E2) secretion by inhibiting the expression of MAP3K8
role of p105 (zeige CDH13 Proteine)/Tpl2 signaling in lung homeostasis
rs1042058 GG Crohn's disease -risk polymorphism in TPL2 results in a gain-of-function by increasing TPL2 expression and signalling, thereby amplifying Pattern recognition receptor -initiated outcomes.
MAP3K8 is a direct target of miR (zeige MLXIP Proteine)-144-3p, and miR (zeige MLXIP Proteine)-144-3p downregulation is a factor in renal cell carcinoma (zeige MOK Proteine) progression through potentiation of MAP3K8 expression.
Taken together, these results suggest that Cot kinase might play a critical role in Helicobacter pylori type IV secretion apparatus-dependent early IL-8 (zeige IL8 Proteine) secretion and CagA (zeige S100A8 Proteine)-dependent late IL-8 (zeige IL8 Proteine) secretion as an alternative signaling molecule in the Erk (zeige EPHB2 Proteine) pathway.
Studies indicate that Tpl2, a MAP3K, participates in a broad range of cancer-related signaling pathways and induces tumorigenesis and progression of many cancers.
the results of the present study demonstrated that the miR (zeige MLXIP Proteine)-509-3p RCC (zeige XRCC1 Proteine) suppressor was a significant regulator of the MAP3K8 oncogene (zeige RAB1A Proteine), suggesting that it may have a potential therapeutic role in the treatment of renal cell carcinoma (zeige MOK Proteine)
Describe spontaneous S. xylosus infection in a genetically modified murine model. S. xylosus infection in Rag1 (zeige RAG1 Proteine)-/-Tpl2-/- mice correlated with disseminated bacteria and elevated numbers of circulating monocytes.
study to determine whether Tpl2 influences the immune response generated to the extracellular bacterium Citrobacter rodentium, which induces a mixed Th1 (zeige HAND1 Proteine) and Th17 response; findings confirm the importance of Tpl2 in driving the development of the proinflammatory Th1 (zeige HAND1 Proteine) lineage as well as promoting IL-17A (zeige IL17A Proteine) expression and neutrophil recruitment during infection with extracellular bacteria
TPL-2-regulated Ccl24 (zeige CCL24 Proteine) in CD11c (zeige ITGAX Proteine)+CD11b (zeige ITGAM Proteine)+ cells prevents accelerated type-2 mediated immunity to H. polygyrus.
role of p105 (zeige NEDD9 Proteine)/Tpl2 signaling in lung homeostasis
this study shows that TPL-2 deficiency leads to severe house duct mite-induced airway allergy, when compared with wild-type mice
The kinase TPL2 activates ERK (zeige EPHB2 Proteine) and p38 (zeige CRK Proteine) signaling to promote neutrophilic inflammation
TPL2 kinase is a crucial signaling factor in iNKT cells and major mediator of hepatic inflammation.
Taken together this study identified that TPL-2 regulated TH2-mediated inflammation by supporting lipolysis and M2 macrophage activation, preventing TH2 cell expansion and downstream immunopathology and fibrosis.
Map3k8 decreases apoptosis of monocytes and enhances CCR2 (zeige CCR2 Proteine) expression on Ly6C(high)CD11c (zeige ITGAX Proteine)(low) monocytes of atherosclerotic ApoE (zeige APOE Proteine)(-/-) mice fed an high fat diet.
results demonstrate that Tpl2 promotes inflammation in part by constraining FoxP3 (zeige FOXP3 Proteine) expression and Treg immunosuppressive functions.
This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.
mitogen-activated protein kinase kinase kinase 8
, Ewing sarcoma transformant
, cot (cancer Osaka thyroid) oncogene
, proto-oncogene c-Cot
, proto-oncogene serine/threoine protein kinase
, tumor progression locus 2
, COT proto-oncogene serine/threonine-protein kinase
, cancer Osaka thyroid oncogene
, cancer Osaka thyroid, oncogene
, mitogen activated protein kinase kinase kinase 8
, serine/threonine-protein kinase cot
, serine/threonine kinase (Tpl-2)