MAP3K8 Proteine (MAP3K8)

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

• mitogen-activated protein kinase kinase kinase 8 (MAP3K8)
• mitogen-activated protein kinase kinase kinase 8 (map3k8)
• mitogen-activated protein kinase kinase kinase 8 (Map3k8)

• c-COT Protein
• Cot Protein
• Cot/Tpl2 Protein
• D17TPL2 Protein
• Est Protein
• Alle Synonyme
• Estf Protein
• MAP3K8 Protein
• MEKK8 Protein
• Tpl-2 Protein
• Tpl2 Protein

mitogen-activated protein kinase kinase kinase 8 , Ewing sarcoma transformant , cot (cancer Osaka thyroid) oncogene , proto-oncogene c-Cot , proto-oncogene serine/threoine protein kinase , tumor progression locus 2 , COT proto-oncogene serine/threonine-protein kinase , cancer Osaka thyroid oncogene , cancer Osaka thyroid, oncogene , mitogen activated protein kinase kinase kinase 8 , serine/threonine-protein kinase cot , serine/threonine kinase (Tpl-2)