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anti-Human BIM Antikörper:
anti-Mouse (Murine) BIM Antikörper:
anti-Rat (Rattus) BIM Antikörper:
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Human Polyclonal BIM Primary Antibody für ELISA, IHC - ABIN4284640
Zhang, Gillespie, Borrow, Hersey: The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. in Molecular cancer therapeutics 2004
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Human Polyclonal BIM Primary Antibody für WB - ABIN222941
Chen, Huang, Wang: Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. in Blood 2007
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Human Polyclonal BIM Primary Antibody für ELISA, WB - ABIN250248
Jiang, Lucas, Avery-Kiejda, Wade, deBock, Thorne, Allen, Hersey, Zhang: Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. in Cancer research 2008
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Human Polyclonal BIM Primary Antibody für IHC (p), WB - ABIN388101
Chen, Zhou: Caspase cleavage of BimEL triggers a positive feedback amplification of apoptotic signaling. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Human Polyclonal BIM Primary Antibody für IHC - ABIN965669
Fukazawa, Noguchi, Masumi, Murakami, Uehara: BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors. in Molecular cancer therapeutics 2004
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Human BIM Primary Antibody für IHC - ABIN965668
Luciano, Jacquel, Colosetti, Herrant, Cagnol, Pages, Auberger: Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. in Oncogene 2003
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Human Polyclonal BIM Primary Antibody für IF (p), IHC (p) - ABIN682873
Gogada, Yadav, Liu, Tang, Zhang, Schneider, Seshadri, Sun, Aldaz, Tang, Chandra: Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. in The Journal of biological chemistry 2013
Cloning and functional analysis of the bim gene.
FoxO3a (zeige FOXO3 Antikörper) overexpression increased the transcription and protein expression of Bcl2like protein 11 and cyclindependent kinase inhibitor 1B, and inhibited cyclin D1 (zeige CCND1 Antikörper) transcription and expression.
Data indicate that miR (zeige MLXIP Antikörper)-34a enhanced the sensitivity to cisplatin by upregulation of c-Myc (zeige MYC Antikörper) and Bim pathway.
Modulation of MEK (zeige MAP2K1 Antikörper)/ERK (zeige EPHB2 Antikörper)-dependent Bim and Mcl-1 (zeige MCL1 Antikörper) degradation critically mediates sensitivity and resistance of EGFR (zeige EGFR Antikörper)-mutant non-small cell lung cancer (NSCLC)cells to AZD9291 and hence is an effective strategy to overcome acquired resistance to AZD9291
TMEM16A (zeige ANO1 Antikörper) expression was found to correlate with greater tumor size, less Bim expression, and less apoptotic activity overall in head and neck squamous cell carcinomas (HNSCCs).
Hypermethylation of the proapoptotic genes BCL2 L11 and TNFRSF25 (zeige TNFRSF25 Antikörper) is observed in pleomorphic adenoma of the salivary glands. However, this phenomenon did not impact mRNA transcription.
Data suggest that regulation of pancreatic beta-cell function and survival/apoptosis involves alternative splicing modulated by key splicing regulator (zeige PTBP2 Antikörper) SRP55 (zeige SRSF6 Antikörper); SRP55 (zeige SRSF6 Antikörper)-regulated alternative splicing includes modulation of function of pro-apoptotic proteins (BIM, BAX (zeige BAX Antikörper)), JNK (zeige MAPK8 Antikörper) signaling, and endoplasmic reticulum stress. (SRP55 (zeige SRSF6 Antikörper) = pre-mRNA-splicing factor SRP55 (zeige SRSF6 Antikörper); BAX (zeige BAX Antikörper) = apoptosis regulator BAX (zeige BAX Antikörper))
Bim expression was significantly different in the four molecular subtypes of breast cancer.
BIM deletion is a significant predictor of shorter PFS and OS on EGFR (zeige EGFR Antikörper)-TKIs. Further studies to determine its effect on response to other BIM-dependent therapeutic agents are needed, so that alternative treatment strategies may be devised.
These findings indicate the importance of developing HDAC3 (zeige HDAC3 Antikörper)-selective inhibitors, and their combined use with osimertinib, for treating EGFR (zeige EGFR Antikörper)-mutated lung cancers carrying the BIM deletion polymorphism
Low BIM expression is associated with renal cell carcinoma (zeige MOK Antikörper).
data suggest a role for BIM in regulating mitochondrial bioenergetics and metabolism and support the idea that regulation of metabolism and cell death are connected.
the nuclear receptor NCoR1 suppresses Bim1 to inhibit negative selection and promote thymocyte survival.
Proapoptotic proteins BIM and PUMA (zeige BBC3 Antikörper) are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL (zeige BCL2L1 Antikörper).
Increased expression of miR-214 suppresses PTEN expression and represses Bim1 expression.
Study provides evidence that Bim transcription which is dependent of FOXO3A (zeige FOXO3 Antikörper) protects mice from a high fat diet via inhibition of activation of the NLRP3 (zeige NLRP3 Antikörper) inflammasome by facilitating autophagy flux in Kupffer cells.
The mitochondrial apoptotic pathway, activated by BH3-only (zeige BBC3 Antikörper) proteins, BIM and PUMA (zeige BBC3 Antikörper), is essential for endoplasmic reticulum stress-induced cell death; DR5 (zeige TNFRSF10B Antikörper) as well as caspase-8 (zeige CASP8 Antikörper) are not required for this process.
We propose that the GC-induced mitochondrial accumulation of Bax (zeige BAX Antikörper) and the interaction between the GR and Bim, Bcl-xL (zeige BCL2L1 Antikörper) and Bak (zeige BAK1 Antikörper) could play a role in the regulation of thymocyte apoptosis.
Bcl2l11 as the direct target of miR (zeige MLXIP Antikörper)-9 and manipulation of miR (zeige MLXIP Antikörper)-9 induces the corresponding changing of Bcl2l11 protein level.
these data suggest that the Bim may be a novel therapeutic target in the treatment of systemic lupus erythematosus.
Data show that the induction of BIM in the MYC (zeige MYC Antikörper)- and RAS-driven leukemia is mediated by the downregulation of miR-17-92, and suggest that induction of BIM-mediated apoptosis may be a therapeutic approach for acute lymphoblastic leukemia (ALL).
Pseudorabies virus glycoprotein gE-mediated ERK 1 (zeige MAPK3 Antikörper)/2 phosphorylation also occurs in epithelial cells and in these cells, gE-mediated ERK 1 (zeige MAPK3 Antikörper)/2 signaling is associated with degradation of the pro-apoptotic protein Bim.
BIMEL expression is regulated in porcine cumulus cells by oocyte secreted factor GDF9 (zeige GDF9 Antikörper).
It was concluded that apoptotic cumulus cells, in which BIM(EL) up-regulation was involved, accelerated oocyte aging and degeneration in vitro via a paracrine action.
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
, Bcl-2 interacting mediator of cell death
, bcl-2 interacting mediator of cell death
, bcl-2 interacting protein Bim
, bcl-2-like protein 11
, bcl-2-related ovarian death agonist
, Bcl2 interacting mediator of cell death
, bcl2-interacting mediator of cell death
, Bcl-2 related apoptotic gene product BimL
, bcl-2-related ovarian death protein