This is a synthetic peptide designed for use in combination with anti-SAP18 antibody (Catalog #: ARP38690_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. SAP18 is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.
Alias Symbols: SAP18P, 2HOR0202
Protein Interaction Partner: HDAC1,IKZF1,NOL12,POLE2,RPS3A,SUFU,TADA3,ATP5L,C6orf211,DDOST,DDX3X,EIF3E,GLI1,GLI3,KIAA1279,NOL12,NSF,OSBPL10,POLE2,RGS10,RPN2,RPS3A,SIN3A,Shh,Sin3a,Sufu,TADA3,YARS