This is a synthetic peptide designed for use in combination with anti-RCC1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
RCC1
(Regulator of Chromosome Condensation 1 (RCC1))
Synonyme
Chc1 Peptide, zgc:65796 Peptide, zgc:77114 Peptide, wu:fj77f08 Peptide, rcc1 Peptide, chc1-a Peptide, BJ1 Peptide, CG10480 Peptide, CG18640 (Bj1) Peptide, Dmel\\CG10480 Peptide, RCC1 Peptide, RanGEF Peptide, Rcc1 Peptide, dRCC1 Peptide, inxs Peptide, sdt Peptide, xrcc1 Peptide, chc1-b Peptide, MGC115703 Peptide, MGC132085 Peptide, CHC1 Peptide, RCC1-I Peptide, SNHG3-RCC1 Peptide, 4931417M11Rik Peptide, AI326872 Peptide, regulator of chromosome condensation 1 Peptide, regulator of chromosome condensation 1 L homeolog Peptide, Regulator of chromosome condensation 1 Peptide, N terminal fragment of RCC1; similar to S. cerevisiae SRM1 (YGL097W) guanine nucleotide exchange factor for Gsp1 GTPase involved in assembly of nuclear pore complex; frameshifted Peptide, regulator of chromosome condensation 1 S homeolog Peptide, rcc1 Peptide, RCC1 Peptide, rcc1.L Peptide, Rcc1 Peptide, rcc1.S Peptide
Hintergrund
RCC1 is a Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.
Alias Symbols: CHC1, RCC1-I, SNHG3-RCC1
Protein Interaction Partner: CDK1,CHKA,CSNK1A1,HIST2H2AA3,HIST2H2BE,KPNA3,NUP98,PTMA,RAN,RANBP1,RANBP3,RCC1,XPO1,CSNK1A1,DIS3,H2AFY,KPNA3,KPNA4,KPNB1,METTL11A,RAN,RANBP3,TAL1,XPO1