This is a synthetic peptide designed for use in combination with anti-POU1F1 antibody (Catalog #: ARP31418_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 of mammals, and Unc-86 of C. elegans. PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding growth hormone and prolactin. PIT1 is also important for regulation of the genes encoding prolactin and thyroid-stimulating hormone beta subunit by thyrotropin-releasing hormone and cyclic AMP.
Alias Symbols: PIT1, CPHD1, GHF-1, Pit-1, POU1F1a
Protein Interaction Partner: CREBBP,ETS1,GATA2,JUN,NR1I2,NR1I3,NR3C1,PITX1,GATA2,JUN,NR1I2,NR1I3,NR3C1,PITX1,PPARA,PPARG,VDR