Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (Middle Region) Peptid

Details zu Produkt Nr. ABIN981737, Anbieter: Anmelden zum Anzeigen
Proteinname
  • CALM
  • CLTH
  • LAP
  • PAP180
  • fit-1
  • fit1
  • mKIAA4114
  • Calm
  • phosphatidylinositol binding clathrin assembly protein
  • PICALM
  • Picalm
Protein Region
Middle Region
Spezies
Human
4
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Optionen
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Geblockter Antikörper anti-Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (Middle Region) Antikörper (ABIN2789681)
Sequenz ALEQHLASLE GKKIKDSTAA SRATTLSNAV SSLASTGLSL TKVDEREKQA
Produktmerkmale This is a synthetic peptide designed for use in combination with anti-PICALM Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Reinigung Purified
Proteinname Phosphatidylinositol Binding clathrin Assembly Protein (PICALM)
Hintergrund This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10,11)(p13,q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease.

Alias Symbols: CALM, CLTH, LAP

Protein Interaction Partner: AP2A1,CASP3,CASP8,CLTC,CLTCL1,DDIT3,EHD2,PLCG1,CLTC,DDIT3,PLCG1

Protein Size: 652
Molekulargewicht 71 kDa
Gen-ID 8301
NCBI Accession NM_007166, NP_009097
UniProt Q13492
Applikations-hinweise Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Rekonstitution Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration 1 mg/mL
Buffer Final peptide concentration is 1 mg/mL in PBS.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.