Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) (N-Term) Peptid
MAP4K4
Reaktivität: Human
Wirt: Synthetic
BP, IHC, WB
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- Target Alle MAP4K4 Produkte
- MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))
- Protein Region
- N-Term
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-MAP4K4 antibody (Catalog #: ARP49031_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))
- Synonyme
- FLH21957 Peptide, HGK Peptide, MEKKK4 Peptide, NIK Peptide, 9430080K19Rik Peptide, AU043147 Peptide, AU045934 Peptide, AW046177 Peptide, Nik Peptide, mitogen-activated protein kinase kinase kinase kinase 4 Peptide, MAP4K4 Peptide, Map4k4 Peptide
- Hintergrund
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MAP4K4 is the serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. MAP4K4 appears to act upstream of the JUN N-terminal pathway.The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: FLH21957, FLJ10410, FLJ20373, FLJ90111, HGK, KIAA0687, NIK, MEKKK4
Protein Interaction Partner: DOK1,GBP3,ITGB1,MAP3K7,NCK1,RAP2A,RASA1,SLC9A1,ATL1,BRCA1,GBP3,ITGB1,MAP3K1,MAP3K7,NCK1,RASA1,ZRANB1
Protein Size: 1166 - Molekulargewicht
- 133 kDa
- Gen-ID
- 9448
- NCBI Accession
- NM_004834, NP_004825
- UniProt
- O95819
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