This is a synthetic peptide designed for use in combination with anti-Klhl12 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
KLHL12
(Kelch-Like 12 (Drosophila) (KLHL12))
Synonyme
zgc:92570 Peptide, wu:fi60g03 Peptide, C3ip1 Peptide, C3IP1 Peptide, DKIR Peptide, hDKIR Peptide, Ski2 like RNA helicase Peptide, kelch like family member 12 L homeolog Peptide, kelch like family member 12 Peptide, kelch-like family member 12 Peptide, kelch-like 12 Peptide, SKIV2L Peptide, klhl12.L Peptide, KLHL12 Peptide, klhl12 Peptide, Klhl12 Peptide
Hintergrund
Klhl12 serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. It negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.