ITGB3BP
(Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
Protein Region
N-Term
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Produktmerkmale
This is a synthetic peptide designed for use in combination with anti-ITGB3BP antibody (Catalog #: ARP54999_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Alias Symbols: CENP-R, CENPR, HSU37139, NRIF3, TAP20
Protein Interaction Partner: MTA1,ARFIP2,CCNA2,COL4A3BP,DDX24,ESR1,ITGB3,ITGB3BP,ITGB5,MTA1,NFKB1,RECQL5,RXRA,ARFIP2,CCNA2,COL4A3BP,DDX24,ITGB3,ITGB3BP,ITGB5,NFKB1,RECQL5,RELA,RXRA,RXRG,THRA