This is a synthetic peptide designed for use in combination with anti-FAM175A Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
FAM175A
Reaktivität: Human, Affe
Wirt: Synthetic
BP, WB, ICo, IDe
Applikationshinweise
Each Investigator should determine their own optimal working dilution for specific applications.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
CCDC98 (FAM175A)
(Family with Sequence Similarity 175, Member A (FAM175A))
Synonyme
CCDC98 Peptide, abra1 Peptide, ccdc98 Peptide, fam175a Peptide, ABRA1 Peptide, 3830405G04Rik Peptide, 5630400M01Rik Peptide, AI506069 Peptide, AL024423 Peptide, AV118690 Peptide, Ccdc98 Peptide, RGD1305287 Peptide, zgc:103522 Peptide, abraxas 1, BRCA1 A complex subunit Peptide, Coiled-coil domain-containing protein 98 Peptide, BRCA1 A complex subunit Peptide, family with sequence similarity 175 member A Peptide, abraxas 2a, BRISC complex subunit Peptide, abraxas 1, BRCA1 A complex subunit S homeolog Peptide, ABRAXAS1 Peptide, abraxas1 Peptide, Abraxas1 Peptide, FAM175A Peptide, abraxas2a Peptide, abraxas1.S Peptide
Hintergrund
FAM175A is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
Alias Symbols: ABRA1, CCDC98, FLJ11520, FLJ12642, FLJ13614
Protein Interaction Partner: BRCA1,UIMC1,BABAM1,BARD1,BRCA1,BRCC3,BRE,HSPA4,UBC,UIMC1