E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3) Peptid
ELF3
Reaktivität: Human, Maus
Wirt: Synthetic
BP, WB
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- Target Alle ELF3 Produkte
- ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))
- Spezies
- Human, Maus
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-Elf3 antibody (Catalog #: ARP40156_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ELF3 (E74-Like Factor 3 (Ets Domain Transcription Factor, Epithelial-Specific) (ELF3))
- Synonyme
- ert Peptide, esx Peptide, epr-1 Peptide, ese-1 Peptide, ESE-1 Peptide, ESX Peptide, jen Peptide, EPR-1 Peptide, ERT Peptide, E74 like ETS transcription factor 3 Peptide, E74-like factor 3 Peptide, elf3 Peptide, Elf3 Peptide, ELF3 Peptide
- Hintergrund
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Elf3 is a transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. It acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity). It also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. IT represses KRT4 promoter activity (By similarity). It may play an important role in epithelial cell differentiation and tumorigenesis and may be a critical downstream effector of the ERBB2 signaling pathway (By similarity). It may be associated with mammary gland development and involution. It plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
Alias Symbols: ESE-1, ESX, jen
Protein Size: 371 - Molekulargewicht
- 41 kDa
- Gen-ID
- 13710
- NCBI Accession
- NM_007921, NP_031947
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