CTDSP2 (CTD (Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2) (Middle Region) Peptid
Reaktivität: Human
Wirt: Synthetic
BP, WB
-
- Target
- CTDSP2 (CTD (Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2)
- Protein Region
- Middle Region
- Spezies
- Human
-
Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- ASYIFHPENA VPVQSWFDDM ADTELLNLIP IFEELSGAED VYTSLGQLRA
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-CTDSP2 Antibody(ARP52097_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
-
-
- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- CTDSP2 (CTD (Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2)
- Substanzklasse
- Peptide
- Hintergrund
-
CTDSP2 preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A.CTDSP2 negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. CTDSP2 is recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.CTDSP2 may contribute to the development of sarcomas.
Alias Symbols: OS4, PSR2, SCP2
Protein Interaction Partner: AR,POLR2A,SNAI1
Protein Size: 271 - Molekulargewicht
- 31 kDa
- Gen-ID
- 10106
- NCBI Accession
- NM_005730, NP_005721
- UniProt
- O14595
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