Activating Transcription Factor 3 (ATF3) (Middle Region) Peptid
ATF3
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle ATF3 Produkte
- ATF3 (Activating Transcription Factor 3 (ATF3))
- Protein Region
- Middle Region
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-ATF3 antibody (Catalog #: ARP36556_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Each Investigator should determine their own optimal working dilution for specific applications.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ATF3 (Activating Transcription Factor 3 (ATF3))
- Synonyme
- zgc:55526 Peptide, ATF3 Peptide, LRG-21 Peptide, LRF-1 Peptide, LRFI Peptide, atf-3 Peptide, activating transcription factor 3 Peptide, activating transcription factor 3 L homeolog Peptide, atf3 Peptide, ATF3 Peptide, Atf3 Peptide, atf3.L Peptide
- Hintergrund
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This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. ATF3 represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.
Alias Symbols: -
Protein Interaction Partner: ATF3,TP53,ATF3,BATF3,C1orf103,DDIT3,FGFR3,IGSF21,JUN,JUND,NFKB1,NUF2,SMAD3,TP53,ATF4,C1orf103,DDIT3,FGFR3,IGSF21,JUN,JUND,SMAD3,TP53
Protein Size: 181 - Molekulargewicht
- 20 kDa
- Gen-ID
- 467
- NCBI Accession
- NM_001674, NP_001665
- UniProt
- P18847
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