phosphorylated Adaptor For RNA Export (PHAX) (Middle Region) Peptid
PHAX
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle PHAX Produkte
- PHAX (phosphorylated Adaptor For RNA Export (PHAX))
- Protein Region
- Middle Region
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- IMNGSRRRTP GGVFLNLLKN TPSISEEQIK DIFYIENQKE YENKKAARKR
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- PHAX Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- PHAX (phosphorylated Adaptor For RNA Export (PHAX))
- Synonyme
- RNUXA Peptide, 2810055C14Rik Peptide, 4933427L19Rik Peptide, AU018701 Peptide, AU018854 Peptide, D18Ertd65e Peptide, Rnuxa Peptide, p55 Peptide, phosphorylated adaptor for RNA export Peptide, PHAX Peptide, Phax Peptide
- Hintergrund
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A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.
Alias Symbols: RNUXA
Protein Size: 394 - Gen-ID
- 51808
- NCBI Accession
- NM_032177, NP_115553
- UniProt
- Q9H814
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