Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (Middle Region) Peptid
TNFSF10
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle TRAIL (TNFSF10) Produkte
- TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
- Protein Region
- Middle Region
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- SKSGIACFLK EDDSYWDPND EESMNSPCWQ VKWQLRQLVR KMILRTSEET
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- TNFSF10 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) (AA 114-281) peptide
TNFSF10 Reaktivität: Human Wirt: Escherichia coli (E. coli) SDS Dithiothreitol (DTT)
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- TRAIL (TNFSF10) (Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10))
- Synonyme
- APO2L Peptide, Apo-2L Peptide, CD253 Peptide, TL2 Peptide, TRAIL Peptide, A330042I21Rik Peptide, AI448571 Peptide, APO-2L Peptide, Ly81 Peptide, Trail Peptide, tl2 Peptide, apo2l Peptide, cd253 Peptide, trail Peptide, apo-2l Peptide, trail1 Peptide, xtrail1 Peptide, tnfsf10l2 Peptide, zgc:92320 Peptide, TNLG6A Peptide, TNF superfamily member 10 Peptide, tumor necrosis factor (ligand) superfamily, member 10 Peptide, tumor necrosis factor superfamily member 10 Peptide, TNF superfamily member 10 S homeolog Peptide, TNFSF10 Peptide, Tnfsf10 Peptide, tnfsf10.S Peptide, tnfsf10 Peptide
- Hintergrund
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The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: TL2, APO2L, CD253, TRAIL, Apo-2L, TNLG6A
Protein Size: 281 - Gen-ID
- 8743
- NCBI Accession
- NM_001190942, NP_001177871
- UniProt
- P50591
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