Ubiquitin Specific Peptidase 20 (USP20) (Middle Region) Peptid
USP20
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle USP20 Produkte
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
- Protein Region
- Middle Region
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- LHEELKEPVV ATVALTEARD SDSSDTDEKR EGDRSPSEDE FLSCDSSSDR
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- USP20 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
- Synonyme
- USP20 Peptide, vdu2 Peptide, lsfr3a Peptide, LSFR3A Peptide, VDU2 Peptide, hVDU2 Peptide, 1700055M05Rik Peptide, AI467231 Peptide, Vdu2 Peptide, im:7151955 Peptide, zgc:63661 Peptide, universal stress protein Peptide, ubiquitin specific peptidase 20 Peptide, ubiquitin specific peptidase 20 L homeolog Peptide, RR_RS15875 Peptide, USP20 Peptide, usp20 Peptide, Usp20 Peptide, usp20.L Peptide
- Hintergrund
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This gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel-Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL-E3 ligase complex, this enzyme deubiquitinates hypoxia-inducible factor (HIF)-1 alpha and thereby causes increased expression of HIF-1alpha targeted genes which play a role in angiogenesis, glucose metabolism, cell proliferation and metastasis. The enzyme encoded by this gene also regulates G-protein coupled receptor signaling by mediating the deubiquitination of beta-2 adrenergic receptor (ADRB2). This enzyme is a ubiquitously expressed thiolester hydrolase. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: VDU2, hVDU2, LSFR3A
Protein Size: 914 - Gen-ID
- 10868
- NCBI Accession
- NM_001008563, NP_001008563
- UniProt
- Q9Y2K6
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