ATG14 Autophagy Related 14 (ATG14) (Middle Region) Peptid
ATG14
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle ATG14 Produkte
- ATG14 (ATG14 Autophagy Related 14 (ATG14))
- Protein Region
- Middle Region
- Spezies
- Human
- Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- NEEMEKNSEG LLKTKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti- ATG14 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ATG14 (ATG14 Autophagy Related 14 (ATG14))
- Synonyme
- ATG14L Peptide, BARKOR Peptide, KIAA0831 Peptide, 4832427M01 Peptide, Atg14L Peptide, D14Ertd114e Peptide, D14Ertd436e Peptide, RGD1304610 Peptide, autophagy related 14 Peptide, ATG14 Peptide, Atg14 Peptide
- Hintergrund
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Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1. Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes. Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1. Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK. Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion. Modulates the hepatic lipid metabolism.
Alias Symbols: ATG14L, BARKOR, KIAA0831
Protein Size: 492 - Gen-ID
- 22863
- NCBI Accession
- NM_014924, NP_055739
- UniProt
- Q6ZNE5
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