This is a synthetic peptide designed for use in combination with anti-GPS2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
GPS2
(G Protein Pathway Suppressor 2 (GPS2))
Synonyme
gps2 Peptide, MGC68832 Peptide, MGC63588 Peptide, zgc:63588 Peptide, GPS2 Peptide, MGC133909 Peptide, amf-1 Peptide, AMF-1 Peptide, AI505953 Peptide, G protein pathway suppressor 2 Peptide, G protein pathway suppressor 2 L homeolog Peptide, gps2 Peptide, gps2.L Peptide, GPS2 Peptide, Gps2 Peptide
Hintergrund
This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.