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Coagulation Factor II (thrombin) Receptor (F2R) Peptid
F2R
Agon
Produktdetails
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Target
Alle PAR1 (F2R) Produkte
PAR1 (F2R)
(Coagulation Factor II (thrombin) Receptor (F2R))
Applikation
Agonist (Agon)
Aufreinigung
Serum
Reinheit
95 %
Alternativen
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Anwendungsinformationen
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Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Lagerung
-20 °C
Referenzen
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Simmons, Lee, Möller, Weinstein : "Thrombin induces release of proinflammatory chemokines interleukin-8 and interferon-?-induced protein-10 from cultured human fetal astrocytes. " in: Neuroreport , Vol. 24 , Issue 1 , pp. 36-40 , (2012 ) (PubMed ).
Weinstein, Zhang, Kutlubaev, Lee, Bishop, Andersen, Hanisch, Möller : "Thrombin-induced regulation of CD95(Fas) expression in the N9 microglial cell line: evidence for involvement of proteinase-activated receptor(1) and extracellular signal-regulated kinase 1/2. " in: Neurochemical research , Vol. 34 , Issue 3 , pp. 445-52 , (2009 ) (PubMed ).
Weinstein, Ettinger, Zhang, Andersen, Hanisch, Möller : "Thrombin regulates CD40 expression in microglial cells. " in: Neuroreport , Vol. 19 , Issue 7 , pp. 757-60 , (2008 ) (PubMed ).
Antigendetails
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Target
PAR1 (F2R)
(Coagulation Factor II (thrombin) Receptor (F2R))
Synonyme
CF2R Peptide, HTR Peptide, PAR-1 Peptide, PAR1 Peptide, TR Peptide, Par1 Peptide, TRGPC Peptide, AI482343 Peptide, Cf2r Peptide, ThrR Peptide, Par-1 Peptide, f2r-a Peptide, par1 Peptide, coagulation factor II thrombin receptor Peptide, coagulation factor II (thrombin) receptor Peptide, coagulation factor 2 (thrombin) receptor L homeolog Peptide, F2R Peptide, F2r Peptide, f2r.L Peptide
Hintergrund
This hexapeptide corresponding to residues 42-47 of the thrombin receptor has been shown to be a thrombin receptor activator. It caused half-maximal platelet aggregation at approx. 0.8 uM and was 5 times more potent than the parent peptide H-8105. In addition, SFLLRN is effective in causing tyrosine phosphorylation, inhibition of cAMP formation, and an increase in cytosolic Ca2+.
Zuletzt angesehen
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