This is a synthetic peptide designed for use in combination with anti-UHRF1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Rekonstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Konzentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Handhabung
Avoid repeat freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target
UHRF1
(Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))
Synonyme
ICBP90 Peptide, Np95 Peptide, RNF106 Peptide, hNP95 Peptide, hUHRF1 Peptide, AL022808 Peptide, NP95 Peptide, fb97f09 Peptide, wu:fb97f09 Peptide, zgc:63539 Peptide, UHRF1 Peptide, ubiquitin like with PHD and ring finger domains 1 Peptide, ubiquitin-like, containing PHD and RING finger domains, 1 Peptide, ubiquitin-like with PHD and ring finger domains 1 Peptide, UHRF1 Peptide, Uhrf1 Peptide, uhrf1 Peptide
Hintergrund
This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.