HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1) (N-Term) Peptid
HACE1
Reaktivität: Human
Wirt: Synthetic
BP, WB
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- Target Alle HACE1 Produkte
- HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))
- Protein Region
- N-Term
- Spezies
- Human
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Quelle
- Synthetic
- Applikation
- Blocking Peptide (BP), Western Blotting (WB)
- Sequenz
- RARTVELPED NETAVYTLMP MVMADQHRSV SELLSNSKFD VNYAFGRVKR
- Produktmerkmale
- This is a synthetic peptide designed for use in combination with anti-HACE1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Aufreinigung
- Purified
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Konzentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handhabung
- Avoid repeat freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HACE1 (HECT Domain and Ankyrin Repeat Containing, E3 Ubiquitin Protein Ligase 1 (HACE1))
- Synonyme
- HACE1 Peptide, 1700042J16Rik Peptide, A730034A22Rik Peptide, BC025474 Peptide, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 Peptide, HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 L homeolog Peptide, HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1 Peptide, HACE1 Peptide, hace1 Peptide, hace1.L Peptide, Hace1 Peptide
- Hintergrund
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HACE1 is a E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. It acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. It acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. HACE1 specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. It may also act as a transcription regulator via its interaction with RARB.
Alias Symbols: -
Protein Size: 694 - Molekulargewicht
- 76 kDa
- Gen-ID
- 57531
- NCBI Accession
- NM_020771, NP_065822
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