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Human Monoclonal CPE Primary Antibody für IF, IP - ABIN968159
Cool, Normant, Shen, Chen, Pannell, Zhang, Loh: Carboxypeptidase E is a regulated secretory pathway sorting receptor: genetic obliteration leads to endocrine disorders in Cpe(fat) mice. in Cell 1997
Show all 4 Pubmed References
Human Monoclonal CPE Primary Antibody für IF, IP - ABIN968160
Manser, Fernandez, Loo, Goh, Monfries, Hall, Lim: Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro. in The Biochemical journal 1990
Show all 4 Pubmed References
This study has uncovered a human CPE/NF-alpha1 gene mutation that could lead to comorbidity of dementia and depression, emphasizing the importance of this gene in cognitive function.
CPE through its N'-terminal sequence, forms aggregates with Wnt3a (zeige WNT3A Antikörper) and possible endoplasmic reticulum (ER) stress leading to its loss of function.
we have identified a novel SNP in the CPE gene which results in the loss of its neuroprotective function in cells and may confer neurological disorders in humans
High-level CPE [ carboxypeptidase E] expression was associated with a poor prognosis in early-stage cervical cancer. CPE may serve as a biomarker for predicting PLNM [ pelvic lymph node metastasis ] and survival in these patients.
Low carboxypeptidase E expression is associated with recurrence in early-stage hepatocellular carcinoma.
Down-expression of liver carboxypeptidase E may reduce the secretion of serum cholecystokinin (zeige CCK Antikörper) and contribute to the formation of cholesterol gallstone.
Downregulation of CPE regulates cell proliferation and chemosensitivity in pancreatic cancer.
Disruption of insulin receptor (IR (zeige INSR Antikörper)) expression in beta cells has a direct impact on the expression of the convertase enzyme carboxypeptidase E (CPE) by inhibition of the eukaryotic translation initiation factor (zeige EIF2A Antikörper) Eif4g1 (zeige EIF4G1 Antikörper).
Upregulation of CPE promotes cell proliferation and tumorigenicity in colorectal cancer.
Data suggest that splice variant of carboxypeptidase E (CPE-DeltaN) that CPE-DeltaN expression might be a potential prognostic marker for colorectal cancer patients.
Cpe knockout leads to dysfunction of BDNF (zeige BDNF Antikörper)-TRKB (zeige NTRK2 Antikörper) signaling in hippocampus and lack of long-term potentiation formation.
NF-alpha1 is critical for regulating antiproliferation and cell fate determination, through differentiating embryonic stem cells to GFAP (zeige GFAP Antikörper)-positive astrocytes for normal neurodevelopment.
we show by RNA silencing that CPE and SgIII (zeige SCG3 Antikörper) play a synergistic role in the trafficking of POMC (zeige POMC Antikörper) to granules of the regulated secretory pathway in AtT20 cells
An anti-inflammatory role of CPE in the intestine by influencing local cytokine levels and thus regulating the migration of myeloid immune cells into the mucosa.
This study shown that NF-alpha1-mediated upregulation of hippocampal FGF2 (zeige FGF2 Antikörper) and neurogenesis prevents an onset of chronic stress-induced depressive-like behavior
The neuroprotective effect of CPE-DeltaN against neuronal glutamate (zeige GRIN1 Antikörper) neurotoxicity was mediated by secreted FGF2 (zeige FGF2 Antikörper).
Carboxypeptidase E is an important modulator of RANKL (zeige TNFSF11 Antikörper)-induced osteoclast differentiation.
Report the effects of ovalbumin (zeige OVA Antikörper) sensitization and challenge on oscillatory mechanics of the lung and pulmonary inflammation in obese carboxypeptidase E-deficient mice.
This study has identified CPE as a new neurotrophic factor (zeige NTF3 Antikörper) that can protect neurons against degeneration.
This gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes.
, carboxypeptidase E preproprotein
, carboxypeptidase E-like
, carboxypeptidase H
, cobalt-stimulated chromaffin granule carboxypeptidase
, enkephalin convertase
, insulin granule-associated carboxypeptidase
, prohormone-processing carboxypeptidase