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anti-Human E2F1 Antikörper:
anti-Mouse (Murine) E2F1 Antikörper:
anti-Rat (Rattus) E2F1 Antikörper:
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Human Monoclonal E2F1 Primary Antibody für IP, WB - ABIN967439
Dyson, Dembski, Fattaey, Ngwu, Ewen, Helin: Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. in Journal of virology 1993
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Human Monoclonal E2F1 Primary Antibody für FACS, IHC - ABIN969516
Okazaki, Matsunaga, Okazaki, Utoguchi, Suzuki, Maruyama, Koyanagi, Ohdo: Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice. in Cancer research 2010
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Human Polyclonal E2F1 Primary Antibody für WB - ABIN3044440
Zhou, Lu, Liu, Guo, Liu, Zhou, Yang, Mi, Xu: Platycodin D induces tumor growth arrest by activating FOXO3a expression in prostate cancer in vitro and in vivo. in Current cancer drug targets 2015
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Human Monoclonal E2F1 Primary Antibody für ICC, IF - ABIN153153
Liu, Clements, Zhao, Marmorstein: Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor. in The Journal of biological chemistry 2006
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Human Monoclonal E2F1 Primary Antibody für ELISA, WB - ABIN3201010
Irwin, Marin, Phillips, Seelan, Smith, Liu, Flores, Tsai, Jacks, Vousden, Kaelin: Role for the p53 homologue p73 in E2F-1-induced apoptosis. in Nature 2000
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Human Polyclonal E2F1 Primary Antibody für IF (p), IHC (p) - ABIN670686
Liu, Yang, Jing, Ren, Wei, Zhang, Zhang, Duan, Zhou, Sun: Silica nanoparticle exposure inducing granulosa cell apoptosis and follicular atresia in female Balb/c mice. in Environmental science and pollution research international 2017
Human Monoclonal E2F1 Primary Antibody für ICC, IF - ABIN269710
Zhang, Zhang, Yao, Lowery, Zhang, Huang, Li, Li, Wang, Zhang, Wang, Ellis, Cheerathodi, McCarty, Palmieri, Saunus, Lakhani, Huang, Sahin, Aldape, Steeg, Yu: Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. in Nature 2015
Human Polyclonal E2F1 Primary Antibody für IHC, IHC (p) - ABIN4306768
Zellmer, Schmidt-Heck, Godoy, Weng, Meyer, Lehmann, Sparna, Schormann, Hammad, Kreutz, Timmer, von Weizsäcker, Thürmann, Merfort, Guthke, Dooley, Hengstler, Gebhardt: Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes. in Hepatology (Baltimore, Md.) 2010
Human Monoclonal E2F1 Primary Antibody für CyTOF, ELISA - ABIN4306767
Lee, Pelletier: Dependence of p53-deficient cells on the DHX9 DExH-box helicase. in Oncotarget 2017
Human Polyclonal E2F1 Primary Antibody für ELISA, WB - ABIN2746554
Wang, Dou, Yao, Song: Homocysteine inhibits adipogenesis in 3T3-L1 preadipocytes. in Experimental biology and medicine (Maywood, N.J.) 2012
specific alternate transcripts of activator E2F (zeige E2F2 Antikörper), dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor
These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
Mechanistically, miR (zeige MYLIP Antikörper)-998 operates by repressing dCbl, a negative regulator of EGFR (zeige EGFR Antikörper) signaling. Significantly, dCbl is a critical target of miR (zeige MYLIP Antikörper)-998 since dCbl phenocopies the effects of miR (zeige MYLIP Antikörper)-998 on dE2f1-dependent apoptosis in rbf (zeige ATP5I Antikörper) mutants
also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter
Results show that regulation of e2f1 and PCNA (zeige PCNA Antikörper) by DREF (zeige ZBED1 Antikörper) in vivo is complex and the regulation mechanism may differ with the tissue and/or positions in the tissue.
Loss of dE2F compromises mitochondrial function.
Data propose that the interaction between ORC5 (zeige ORC5 Antikörper) and dE2F1 may reflect a feedback mechanism between replication initiation proteins and dE2F1 that ensures that proliferating cells maintain a robust level of replication proteins for the next cell cycle.
results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1
Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues.
endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE (zeige CCNE1 Antikörper) expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1
This study reveals a molecular pathway involving lncRNA GAS5/E2F1/P27(Kip1 (zeige CDKN1B Antikörper)) which regulates cell proliferation and could be a potential therapeutic target in prostate cancer.
E2F1 induces TINCR transcriptional activity and accelerates gastric cancer progression via activation of TINCR/STAU1 (zeige STAU1 Antikörper)/CDKN2B (zeige CDKN2B Antikörper) signaling axis.
Data show that lncRNA-HIT acted as an oncogene (zeige RAB1A Antikörper) through association with E2F transcription factor 1 protein (E2F1).
Cell proliferation and apoptosis were almost completely abolished in the PAa cells cotreated with TRIM28 (zeige TRIM28 Antikörper) siRNA and etoposide following knockdown of E2F1. The results of our study demonstrated that the combination of TRIM28 (zeige TRIM28 Antikörper) siRNA and etoposide may be effective against nonsmall cell lung cancer (NSCLC)and has the potential of being a new therapeutic tool for future treatment.
These results reveal an additional level of regulation of the stability and the activity of E2F1 by a non-degradative K63-poly-ubiquitination and uncover a novel function for the E3-ubiquitin ligase (zeige MUL1 Antikörper) cIAP1 (zeige BIRC2 Antikörper).
Higher levels of miR (zeige MLXIP Antikörper)-135a in gastric cancer (GC) are associated with shorter survival times and reduced times to disease recurrence. The mechanism whereby miR (zeige MLXIP Antikörper)-135a promotes GC pathogenesis appears to be the suppression of E2F1 expression.
Results provide mechanistic insight into a series of complex, differentiation-specific molecular mechanisms that regulate E2F1 during keratinocyte maturation via multiple events. These events include nucleocytoplasmic transport and changes in ubiquitinylation patterns specifically orchestrated through S403 and T433, and which differ from other mechanisms that regulate E2F1 turnover in undifferentiated cells.
these results suggest that the E2F1/miR19a/PPARalpha (zeige PPARA Antikörper) feedback loop is critical for glioma progression
This study suggests for the first time an involvement of E2F1 copy number variations in testicular germ cell tumor susceptibility and supports previous preliminary data on the importance of AKT (zeige AKT1 Antikörper)/mTOR (zeige FRAP1 Antikörper) signaling pathway in this cancer.
High E2F1 expression is associated with gastric cancer.
p63alpha protein up-regulates heat shock protein 70 (zeige HSP70 Antikörper) expression via E2F1 transcription factor 1 (zeige HNF1A Antikörper), promoting Wasf3/Wave3 (zeige WASF3 Antikörper)/MMP9 (zeige MMP9 Antikörper) signaling and bladder cancer invasion
The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 to recruit EZH2 (zeige EZH2 Antikörper) to diverse repeat sequences.
germ-line loss of E2f1 or E2f3b, but not E2f3a, protected mice against hepatocellular carcinoma
E2F1 hinders skin wound healing by suppressing VEGF (zeige VEGFA Antikörper) expression, neovascularization, and macrophage recruitment. Strategies that target E2F1 may enhance wound healing.
systems-level control of cell cycle arrest by pRB (zeige PGR Antikörper)-E2F and p27 (zeige CDKN1B Antikörper)-CDK (zeige CDK4 Antikörper) regulation, is reported.
TERT (zeige TERT Antikörper) has a role in neointima formation through epigenetic regulation of proliferative E2F1 target gene expression in smooth muscle cells.
inhibition of PDK4 (zeige PDK4 Antikörper) activity in Hepatocellular carcinoma cells increased cyclin E1 (zeige CCNE1 Antikörper), cyclin A2 (zeige CCNA2 Antikörper), and E2F1 proteins.
Data indicate that adenosine and CGS21680 upregulate CD39 (zeige ENTPD1 Antikörper) and CD73 via E2F-1 and CREB (zeige CREB1 Antikörper).
Expression of Kv10.1 (zeige KCNG3 Antikörper) driven by phosphorylated Rb/E2F1 contributes to G2/M progression of cancer and non-transformed cells.
Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia.
Xphb1 represses E2F1 activity.
SIM (zeige SIM2 Antikörper) and SMR1 are involved in hyperphosphorylation of the cell-cycle regulator RBR1 and overexpression of E2F target genes.
S6K1 interacts with retinoblastoma protein RBR via its N-terminal RBR binding motif, promotes its nuclear localization and consequent RBR-dependent repression of cell cycle genes through transcription factor E2FB.
The Arabidopsis (Arabidopsis thaliana) DEL1 gene was identified as a transcriptional target of the classical E2Fb and E2Fc transcription factors.
The authors found that S6K1 associates with the Retinoblastoma-related 1 (RBR1)-E2FB complex and this is partly mediated by its N-terminal LVxCxE motif.
Results suggest that E2FB is one of the key targets for auxin to determine whether cells proliferate or whether they exit the cell cycle, enlarge, and endoreduplicate their DNA.
AtE2Fa and AtE2Fb have specific expression patterns and may play similar but distinct roles during cell cycle progression.
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
, E2-promoter binding factor
, PRB-binding protein E2F-1
, retinoblastoma-associated protein 1
, retinoblastoma-binding protein 3
, transcription factor E2F1
, E2F-1 transcription factor