PAX5 Produkte
(Paired Box 5 (PAX5))
Kategorien
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9\;14)(p13\;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
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Ausgewählte PAX5 Kategorien
PAX5 Antikörper
High quality antibodies with extensive validation data.
PAX5 ELISA Kits
Reliable ELISA kits for a wide range of species.
PAX5 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PAX5 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p), RNAi
Validierungen
- (6)
Kat. Nr.
ABIN562112
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (2)
- (4)
Kat. Nr.
ABIN1098104
Menge
0.1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
IHC, StM
Validierungen
- (5)
Kat. Nr.
ABIN6940256
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene PAX5 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1381403
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN5661953
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PAX5 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124296
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1314071
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1314073
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PAX5 Produkten
: "Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme-like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report." in: Experimental and therapeutic medicine, Vol. 16, Issue 3, pp. 2060-2065, (2018) (PubMed).: "PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene." in: Gene, Vol. 555, Issue 2, pp. 194-202, (2014) (PubMed).
: "The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease." in: Cancer research, Vol. 71, Issue 24, pp. 7345-50, (2011) (PubMed).
: "The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance." in: The Journal of experimental medicine, Vol. 208, Issue 3, pp. 455-67, (2011) (PubMed).
: "Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study. ..." in: Blood, Vol. 115, Issue 15, pp. 3089-97, (2010) (PubMed).
: "Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker." in: American journal of clinical pathology, Vol. 133, Issue 1, pp. 41-8, (2009) (PubMed).
: "Multiple isoforms of PAX5 are expressed in both lymphomas and normal B-cells." in: British journal of haematology, Vol. 147, Issue 3, pp. 328-38, (2009) (PubMed).
: "Transcriptional analysis of the B cell germinal center reaction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2639-44, (2003) (PubMed).
: "Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma." in: Oncogene, Vol. 21, Issue 32, pp. 4908-20, (2002) (PubMed).
: "Frequent expression of the B-cell-specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin." in: Blood, Vol. 94, Issue 9, pp. 3108-13, (1999) (PubMed).
Synonyme und alternative Namen zu PAX5
paired box 5 (PAX5), paired box 5 L homeolog (pax5.L), paired box 5 (Pax5), paired box 5 (pax5), BSAP, EBB-1, KLP, noi, Pax-5, pax2.1, pax2a, PAX5, pax5-a, paxzf-b, Pax[Zf-b], RGD1565236Bezeichner auf Proteinebene für PAX5
- paired box 5
- paired box gene 5 (B-cell lineage specific activator)
- paired box protein Pax-5
- paired box protein Pax-5-like
- B-cell lineage specific activator
- paired box homeotic gene 5
- paired domain gene 5
- transcription factor PAX 5
- XPax-5
- B-cell-specific transcription factor
- Pax5 variant 1
- Pax5 variant 2
- No isthmus protein
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