PC Produkte
(Pyruvate Carboxylase (PC))
Kategorien
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte PC Kategorien
PC Antikörper
High quality antibodies with extensive validation data.
PC ELISA Kits
Reliable ELISA kits for a wide range of species.
PC Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PC Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (6)
Kat. Nr.
ABIN7441475
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IHC
Validierungen
- (3)
Kat. Nr.
ABIN238663
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC, IHC (p)
Validierungen
- (2)
Kat. Nr.
ABIN2890557
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene PC ELISA Kits
Produkt
Reaktivität
Analytical Method
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Kat. Nr.
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Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969792
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6959001
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6959002
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PC Proteine
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Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7399316
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7409011
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
Kat. Nr.
ABIN2730236
Menge
20 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PC Produkten
: "Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntington's disease." in: Chemico-biological interactions, Vol. 315, pp. 108907, (2020) (PubMed).: "Generation of Human Pyruvate Carboxylase Knockout Cell Lines Using Retrovirus Expressing Short Hairpin RNA and CRISPR-Cas9 as Models to Study Its Metabolic Role in Cancer Research." in: Methods in molecular biology (Clifton, N.J.), Vol. 1916, pp. 273-288, (2019) (PubMed).
: "Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1." in: Cell metabolism, Vol. 28, Issue 2, pp. 268-281.e4, (2018) (PubMed).
: "Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis." in: Nature cell biology, Vol. 17, Issue 10, pp. 1317-26, (2015) (PubMed).
: "Diet-induced obesity in the selenocysteine lyase knockout mouse." in: Antioxidants & redox signaling, Vol. 23, Issue 10, pp. 761-74, (2015) (PubMed).
: "Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 beta cells." in: Molecular and cellular endocrinology, Vol. 383, Issue 1-2, pp. 48-59, (2014) (PubMed).
: "Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice." in: Nature medicine, Vol. 20, Issue 11, pp. 1263-9, (2014) (PubMed).
: "Enhanced Ca(2+)-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model." in: Neurobiology of disease, Vol. 58, pp. 192-9, (2013) (PubMed).
: "Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism." in: PLoS pathogens, Vol. 7, Issue 7, pp. e1002124, (2011) (PubMed).
: "Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme." in: Science (New York, N.Y.), Vol. 317, Issue 5841, pp. 1076-9, (2007) (PubMed).
Synonyme und alternative Namen zu PC
Pyruvate carboxylase (PCB), pyruvate carboxylase b (pcxb), PYruvate Carboxylase (pyc-1), pyruvate carboxylase (PC), pyruvate carboxylase (pyc), pyruvate carboxylase Pyr1 (pyr1), pyruvate carboxylase (CNF00650), Pyruvate carboxylase (PYC1), pyruvate carboxylase (Ndas_1152), pyruvate carboxylase (Ilyop_2503), pyruvate carboxylase (Calni_0495), pyruvate carboxylase (Ftrac_1004), pyruvate carboxylase (Plabr_3574), pyruvate carboxylase (Sgly_2936), pyruvate carboxylase (Celly_0558), pyruvate carboxylase (Hipma_0131), pyruvate carboxylase (Halhy_1567), pyruvate carboxylase (Mesop_1269), pyruvate carboxylase (Pcx), pyruvate carboxylase (Pc), BA4157, BcDNA, BcDNA:GH06348, Dmel\\CG1516, PC, Pc, Pcb, PCB, PCX, Pcx, pyc, wu:fb82g08, wu:fj85g01Bezeichner auf Proteinebene für PC
- CG1516-PA
- CG1516-PB
- CG1516-PD
- CG1516-PE
- CG1516-PG
- CG1516-PI
- CG1516-PJ
- CG1516-PK
- CG1516-PL
- CG1516-PM
- CG1516-PP
- GH06348
- pyruvate carboxykinase
- pyruvate carboxylase
- PYCb
- pyruvate carboxylase, mitochondrial
- PYruvate Carboxylase family member (pyc-1)
- Pyruvate carboxylase
- pyruvate decarboxylase
- pyruvic carboxylase
- PCB
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